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Urinalysis/Function
Kidney Function, Urinalysis, and Diagnostic Tests
| Term | Definition |
|---|---|
| a brown or black urine color may indicate the presence of ? | Bilirubin or melanin |
| How much filtrate is produced by the kidney each day? | 45 gallons of plasma per day |
| most water reabsorption in the kidney occurs in which structure? | proximal tubules |
| What are the 5 roles of the kidneys | removing waste maintaining blood pH Maintaining fluid and electrolytes balance producing hormones forming and excreting urine |
| Which organ is the functional unit of urine formation | Nephron - filtration reabsorption and secretion |
| what hormones increases water reabsorption in the kidneys? | ADH- antidiuretic hormone |
| what hormones inhibits calcium reabsorption in the kidney ? | Calcitonin |
| what hormone in the kidney increases calcium reabsorption? | PTH- parathyroid hormones |
| what hormones in the kidney promotes sodium excretion | ANP- atrial natriuretic peptide |
| what is the renal threshold | When blood concentration exceeds the kidney's ability to reabsorb |
| what hormones in the kidney regulates sodium and potassium | Aldosterone |
| What is the most concentrated component in urine? | Urea |
| The normal adult daily urine output is | 750-2,000mL/day |
| What does a Diuretic do? | Increases urine production |
| Which urine specimen is best for a routine urinalysis | First morning |
| a clean catch midstream specimen is primarily used for | urine cultures |
| the pigment responsible for normal yellow urine color is | urochrome |
| Which hormone stimulates RBC production and is produced by the kidneys? | Erythropoietin |
| Cloudy urine may be caused by | bacteria, crystals, and mucus |
| specific gravity is a measure of | solute concentration |
| a reagent strip positive for nitrites likely indicates | bacterial UTI |
| Which confirmatory test is used to detect reducing sugars? | clinititest |
| which test confirms the presence of protein in urine | SSA test |
| which condition may cause sweet or fruity-smelling urine? | Diabetes mellitus |
| which renal process is responsible for returning useful substance back to the bloodstream? | Selective reabsorption |
| secretions of K+ and H+ in the renal tubules primarily helps regulate what? | acid-base balance |
| which ions is secreted to help regulate potassium levels in the blood | potassium |
| what hormone helps regulate blood pressure ? | renin |
| What hormone control calcium level and bone health | active vitamin D3 (calcitriol) |
| which test detect ketones | acetest |
| which test detects bilirubin | Ictotest |
| When should you test a urine culture | within 1-2 hours of collection |
| At what temperature should you store a urine culture? and for how long? | 4-6 Celsius degree and up to 4 hours |
| what is the primary purpose of microscopic urine sediment examination? | Identify formed elements like cells and casts |
| what is the correct centrifugation procedure for urine sediment examination? | 10-15mL urine at 2000 rpm for 5 minutes |
| what is microscope setting is best for scanning casts? | low power (10x) |
| which element is identified under 40x? | RBC and WBC |
| what is a key feature of RBCs in hypotonic (dilute) urine? | Ghost cells |
| which finding strongly indicates a urinary tract infection? | many/moderate amount of bacteria and WBCs |
| which epithelial cell types is the largest and most likely a contaminant? | squamous epithelial cells |
| increase renal tubular epithelial cells indicate damage to which structure? | renal tubules |
| oval fat bodies in urine are associated with which condition? | nephrotic syndrome |
| which microorganism appears as smooth, oval, colorless and may show budding? | yeast |
| what finding is commonly mistaken for RBCS | yeast |
| trichomonas vaginalis may appear in urine due too | vaginal contamination |
| which structure do casts form in? | renal tubules |
| what finding is typically clinically insignificant in both males and females | spermatozoa |
| which artifact can be mistaken for crystals or cells? | fibers or starch granules |
| which microscopic finding is most suggestive of a UTI | WBCs |
| describe WBCs in urine sediment | larger than RBCs, often are neutrophils |
| severe infection often causes WBCs to appear | in clumps |
| what cause an increase of WBCs in urine? | pyelonephritis, glomerulonephritis, renal tubular acidosis, dehydration, fever |
| Increase WBCs from extra-renal causes may be seen in | pancreatitis, cystitis (bladder infection), urethritis, and appendicitis. |
| which epithelial cell type is the largest seen in urine? | squamous epithelial cells |
| an increase number of renal tubular epithelial cells indicate tubular damages such as | acute tubular necrosis pyelonephritis salicylate poisoning kidney transplant rejection |
| which epithelial cell type is round or pear-shaped? | transitional epithelial cell |
| increased renal tubular epithelial cells may indicate | acute tubular necrosis pyelonephritis salicylate poisoning kidney transplant rejection |
| A urine sample with many squamous epithelial cells most likely is an indication of | poorly collected specimen |
| transitonal epithelial cells originate from which area? | renal pelvis, ureter, bladder, upper urethra |
| renal tubular epithelial cells are best characterized by | large round nucleus, flat/cuboidal/columnar shape |
| a patient with kidney transplant rejection may show increased | renal tubular epithelial cells |
| which epithelial cell type is slightly larger than renal tubular cells? | transitional |
| which finding supports tubular injury rather than contamination? | renal tubular epithelial cells |
| which urine microscopy finding is characteristic of nephrotic syndrome ? | oval fat bodies |
| fat in urine is best detected using | microscopic examination |
| a patient with chronic glomerulonephritis may show which microscopic finding? | oval fat bodies |
| bacteria in a poorly collected urine specimen should be reported as | few, moderate, many |
| which finding most strongly supports a true urinary tract infection? | many WBCS and bacteria |
| yeast in urine is commonly associated with? | diabetes mellitus, catheter use or vaginal contamination |
| yeast may be confused with which other urine sediment element? | RBCs |
| which significant crystals produces hexagonal plates | cystine |
| name crystals found in alkaline urine | triple phosphate amorphous phosphate calcium phosphate ammonium biurate calcium carbonate |
| what artifact can be mistaken for Maltese cross? | start granules |
| name the conditions that cause calcium oxalate crystals | ethylene glycol poisoning high oxalate food (spinach) kidney stone formation |
| radiographic dye crystals look similar to cholesterol crystals | true |
| calcium oxalate crystals can appear in acidic, neutral, or alkaline urine | true |
| most crystals are formed in fresh urine | false, most form in vitro after urine is cools in the container |
| sulfonamide crystals are associated with | drug-induced kidney injury |
| which crystals indicate severe liver disease when seen together | leucine and tyrosine |
| "thorn-apple" crystals are associated with | old alkaline urine |
| a tech sees a large flat plates with notched corners in acidic urine? what is the most likely identity | cholesterol |
| which of the following is a normal finding and clinically insignificant | amorphous urates |
| which crystals is yellow, oily, and has concentric rings or striations | leucine |
| hexagonal, colorless plates in acidic urine indicates | cystine |
| a urine sample shows "coffin-lid" crystals, what condition is most likely to occur? | UTI with proteus |
| Which crystal is most commonly associated with kidney stones (lithiasis)? | calcium oxalate |
| which factor most strongly influences the type of crystals formed in urine? | urine pH |
| what condition favors cast formation? | Acidic urine with urinary stasis |
| which condition produces epithelial cell casts | acute tubular necrosis |
| mixed casts usually occur when | two disease processes overlap |
| fatty cats showing a "Maltese cross" appearance under polarized light are most strongly associate with | nephrotic syndrome Diabetes mellitus Glomerulonephritis Renal toxicity Fat embolism |
| waxy casts are associated with | chronic renal failure malignant hypertension renal amyloidosis Diabetic nephropathy Allograft rejection |
| what does a patient with waxy casts indicate | chronic severe renal disease |
| waxy casts are found in patient with | final-stage degenerated casts |
| granular casts generally indicates | renal disease or cell degeneration |
| epithelial cells casts are associated with | viral infections such as CMV nephrotoxic drug exposure kidney transplant rejection |
| epithelial cell casts may be present after exposure to | nephrotoxic agents viruses |
| WBC casts are seen in | acute pyelonephritis Interstitial nephritis lupus nephritis glomerular disease |
| The presence of neutrophils inside a cast indicates | renal infection or inflammation |
| a hyaline cast is frequently present in | physiologic dehydration and following a physical exercise |
| RBC casts are most commonly associated with | acute glomerulonephritis, lupus nephritis, Goodpasture syndrome, subacute bacterial endocarditis, renal trauma, renal infarction, severe pyelonephritis, right-sided congestive heart failure, renal vein thrombosis, periarteritis nodosa. |
| which cast type always indicates renal pathology? | RBC cast |
| a few hyaline casts may be considered | normal or physiologic |
| broad casts are associated with which condition? | dilated or damaged tubules in renal failure, often in end-stage renal disease = serious renal damage |
| what is the primary protein that makes up urinary casts? | Tamm-Horsfall protein (uromodulin) |
| how can a cast form? | urinary stasis acidic pH high solute concentration increase proteins or abnormal ions in the tubules |
| urinary casts are formed in which part of the nephron? | distal convoluted tubule and collecting ducts |
| A female urine sample shows oval yeast cells with budding. This may be due to? | Vaginal contamination |
| the presence of moderate bacteria without WBCs typically indicates | sample contamination |
| no chemical dipstick test can detect which element? | parasites |
| fat embolism and fractures of long bones may cause which urinary finding? | oval fat bodies |
| which organism appears smooth, oval, colorless, and may show budding on microscopy? | yeast |
| parasites in urine are most commonly due to? | vaginal or fecal contamination |
| which condition can produce oval fat bodies? | enclampsia chronic glomerulonephritis diabetes mellitus lipid nephrosis nephrotic syndrome toxic renal poisoning |
| spermatozoa in urine is generally ? | clinically insignificant |