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Urinalysis/Function

Kidney Function, Urinalysis, and Diagnostic Tests

TermDefinition
a brown or black urine color may indicate the presence of ? Bilirubin or melanin
How much filtrate is produced by the kidney each day? 45 gallons of plasma per day
most water reabsorption in the kidney occurs in which structure? proximal tubules
What are the 5 roles of the kidneys removing waste maintaining blood pH Maintaining fluid and electrolytes balance producing hormones forming and excreting urine
Which organ is the functional unit of urine formation Nephron - filtration reabsorption and secretion
what hormones increases water reabsorption in the kidneys? ADH- antidiuretic hormone
what hormones inhibits calcium reabsorption in the kidney ? Calcitonin
what hormone in the kidney increases calcium reabsorption? PTH- parathyroid hormones
what hormones in the kidney promotes sodium excretion ANP- atrial natriuretic peptide
what is the renal threshold When blood concentration exceeds the kidney's ability to reabsorb
what hormones in the kidney regulates sodium and potassium Aldosterone
What is the most concentrated component in urine? Urea
The normal adult daily urine output is 750-2,000mL/day
What does a Diuretic do? Increases urine production
Which urine specimen is best for a routine urinalysis First morning
a clean catch midstream specimen is primarily used for urine cultures
the pigment responsible for normal yellow urine color is urochrome
Which hormone stimulates RBC production and is produced by the kidneys? Erythropoietin
Cloudy urine may be caused by bacteria, crystals, and mucus
specific gravity is a measure of solute concentration
a reagent strip positive for nitrites likely indicates bacterial UTI
Which confirmatory test is used to detect reducing sugars? clinititest
which test confirms the presence of protein in urine SSA test
which condition may cause sweet or fruity-smelling urine? Diabetes mellitus
which renal process is responsible for returning useful substance back to the bloodstream? Selective reabsorption
secretions of K+ and H+ in the renal tubules primarily helps regulate what? acid-base balance
which ions is secreted to help regulate potassium levels in the blood potassium
what hormone helps regulate blood pressure ? renin
What hormone control calcium level and bone health active vitamin D3 (calcitriol)
which test detect ketones acetest
which test detects bilirubin Ictotest
When should you test a urine culture within 1-2 hours of collection
At what temperature should you store a urine culture? and for how long? 4-6 Celsius degree and up to 4 hours
what is the primary purpose of microscopic urine sediment examination? Identify formed elements like cells and casts
what is the correct centrifugation procedure for urine sediment examination? 10-15mL urine at 2000 rpm for 5 minutes
what is microscope setting is best for scanning casts? low power (10x)
which element is identified under 40x? RBC and WBC
what is a key feature of RBCs in hypotonic (dilute) urine? Ghost cells
which finding strongly indicates a urinary tract infection? many/moderate amount of bacteria and WBCs
which epithelial cell types is the largest and most likely a contaminant? squamous epithelial cells
increase renal tubular epithelial cells indicate damage to which structure? renal tubules
oval fat bodies in urine are associated with which condition? nephrotic syndrome
which microorganism appears as smooth, oval, colorless and may show budding? yeast
what finding is commonly mistaken for RBCS yeast
trichomonas vaginalis may appear in urine due too vaginal contamination
which structure do casts form in? renal tubules
what finding is typically clinically insignificant in both males and females spermatozoa
which artifact can be mistaken for crystals or cells? fibers or starch granules
which microscopic finding is most suggestive of a UTI WBCs
describe WBCs in urine sediment larger than RBCs, often are neutrophils
severe infection often causes WBCs to appear in clumps
what cause an increase of WBCs in urine? pyelonephritis, glomerulonephritis, renal tubular acidosis, dehydration, fever
Increase WBCs from extra-renal causes may be seen in pancreatitis, cystitis (bladder infection), urethritis, and appendicitis.
which epithelial cell type is the largest seen in urine? squamous epithelial cells
an increase number of renal tubular epithelial cells indicate tubular damages such as acute tubular necrosis pyelonephritis salicylate poisoning kidney transplant rejection
which epithelial cell type is round or pear-shaped? transitional epithelial cell
increased renal tubular epithelial cells may indicate acute tubular necrosis pyelonephritis salicylate poisoning kidney transplant rejection
A urine sample with many squamous epithelial cells most likely is an indication of poorly collected specimen
transitonal epithelial cells originate from which area? renal pelvis, ureter, bladder, upper urethra
renal tubular epithelial cells are best characterized by large round nucleus, flat/cuboidal/columnar shape
a patient with kidney transplant rejection may show increased renal tubular epithelial cells
which epithelial cell type is slightly larger than renal tubular cells? transitional
which finding supports tubular injury rather than contamination? renal tubular epithelial cells
which urine microscopy finding is characteristic of nephrotic syndrome ? oval fat bodies
fat in urine is best detected using microscopic examination
a patient with chronic glomerulonephritis may show which microscopic finding? oval fat bodies
bacteria in a poorly collected urine specimen should be reported as few, moderate, many
which finding most strongly supports a true urinary tract infection? many WBCS and bacteria
yeast in urine is commonly associated with? diabetes mellitus, catheter use or vaginal contamination
yeast may be confused with which other urine sediment element? RBCs
which significant crystals produces hexagonal plates cystine
name crystals found in alkaline urine triple phosphate amorphous phosphate calcium phosphate ammonium biurate calcium carbonate
what artifact can be mistaken for Maltese cross? start granules
name the conditions that cause calcium oxalate crystals ethylene glycol poisoning high oxalate food (spinach) kidney stone formation
radiographic dye crystals look similar to cholesterol crystals true
calcium oxalate crystals can appear in acidic, neutral, or alkaline urine true
most crystals are formed in fresh urine false, most form in vitro after urine is cools in the container
sulfonamide crystals are associated with drug-induced kidney injury
which crystals indicate severe liver disease when seen together leucine and tyrosine
"thorn-apple" crystals are associated with old alkaline urine
a tech sees a large flat plates with notched corners in acidic urine? what is the most likely identity cholesterol
which of the following is a normal finding and clinically insignificant amorphous urates
which crystals is yellow, oily, and has concentric rings or striations leucine
hexagonal, colorless plates in acidic urine indicates cystine
a urine sample shows "coffin-lid" crystals, what condition is most likely to occur? UTI with proteus
Which crystal is most commonly associated with kidney stones (lithiasis)? calcium oxalate
which factor most strongly influences the type of crystals formed in urine? urine pH
what condition favors cast formation? Acidic urine with urinary stasis
which condition produces epithelial cell casts acute tubular necrosis
mixed casts usually occur when two disease processes overlap
fatty cats showing a "Maltese cross" appearance under polarized light are most strongly associate with nephrotic syndrome Diabetes mellitus Glomerulonephritis Renal toxicity Fat embolism
waxy casts are associated with chronic renal failure malignant hypertension renal amyloidosis Diabetic nephropathy Allograft rejection
what does a patient with waxy casts indicate chronic severe renal disease
waxy casts are found in patient with final-stage degenerated casts
granular casts generally indicates renal disease or cell degeneration
epithelial cells casts are associated with viral infections such as CMV nephrotoxic drug exposure kidney transplant rejection
epithelial cell casts may be present after exposure to nephrotoxic agents viruses
WBC casts are seen in acute pyelonephritis Interstitial nephritis lupus nephritis glomerular disease
The presence of neutrophils inside a cast indicates renal infection or inflammation
a hyaline cast is frequently present in physiologic dehydration and following a physical exercise
RBC casts are most commonly associated with acute glomerulonephritis, lupus nephritis, Goodpasture syndrome, subacute bacterial endocarditis, renal trauma, renal infarction, severe pyelonephritis, right-sided congestive heart failure, renal vein thrombosis, periarteritis nodosa.
which cast type always indicates renal pathology? RBC cast
a few hyaline casts may be considered normal or physiologic
broad casts are associated with which condition? dilated or damaged tubules in renal failure, often in end-stage renal disease = serious renal damage
what is the primary protein that makes up urinary casts? Tamm-Horsfall protein (uromodulin)
how can a cast form? urinary stasis acidic pH high solute concentration increase proteins or abnormal ions in the tubules
urinary casts are formed in which part of the nephron? distal convoluted tubule and collecting ducts
A female urine sample shows oval yeast cells with budding. This may be due to? Vaginal contamination
the presence of moderate bacteria without WBCs typically indicates sample contamination
no chemical dipstick test can detect which element? parasites
fat embolism and fractures of long bones may cause which urinary finding? oval fat bodies
which organism appears smooth, oval, colorless, and may show budding on microscopy? yeast
parasites in urine are most commonly due to? vaginal or fecal contamination
which condition can produce oval fat bodies? enclampsia chronic glomerulonephritis diabetes mellitus lipid nephrosis nephrotic syndrome toxic renal poisoning
spermatozoa in urine is generally ? clinically insignificant
Created by: user-2001025
 

 



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