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Antidysrhythmics

QuestionAnswer
What is class 1 of the antidysrhythmic drugs? NA+ Channel blockers
NA+ Channel blockers Slow the conduction by stabilizing the membrane
1A NA+ Channel blockers Prolong the refectory period - Wider QRS complex and QT interval
1B NA+ Channel blockers Focus on inactive Na channels in ischemic cells in ventricles
1C NA+ Channel blockers Only for most severe ventricle dysrhythmias
Procainamide 1A NA+ Channel blockers
Quinidine 1A NA+ Channel blockers
Lidocaine hydrochloride 1B NA+ Channel blockers
Flecainide 1C NA+ Channel blockers
Disopyramide 1A NA+ Channel blockers
Propafenone 1C NA+ Channel blockers
Contraindications for Quinidine Heart block Structural heart disease Grapefruit juice
Contraindications for Lidocaine Wolff- Parkinson-White syndrome
Contraindications for Flecainide Cardiogenic shock, heart block, AFIB & Aflutter!!!!! - Causes pro-dysrhythmic effect
B-blockers Reduce SA nodal activity = decrease in HR, CO, and AV node conduction Can control supraventricular tachydysrhythmias - A fib and flutter
Propranolol Hydrochloride (+SA) Nonselective B-blocker - decrease in HR, CO, and AV node conduction SA: - HF and AV block - Sinus arrest - Hypotension - Bronchospasm
Amiodarone Hydrochloride Potassium channel blocker - blocks both a and b adrenergic heart stimulation
What ECG changes will you see for Amiodarone QRS widening, PR interval prolongation, and QT interval prolongation
What life-threatening arrhythmias is amiodarone used to treat? Vfib and unstable vtach
SA for amiodarone *Pulmonary toxicity* Hepatotoxic Hypotension, bradycardia, cardiotoxicity Hypo&hyperthyroidism Dermatoxisity Pregnancy toxic
Potassium channel blockers Most commonly used - decrease in HR, CO, and AV node conduction For Vtach, Vfib, Aflutter, Afib (that are resistant to other drugs)
Dronedarone Potassium channel blocker
CCB's Prolong the AV node and reduce av node conduction Used for PSVT, and rate control for AFib and Aflutter
Verapamil CCB
Diltiazem CCB
Adenosine ↓ SA node automaticity, ↓ AV node conduction, and PR interval prolongation. Treats Paroxysmal supraventricular tachycardia Administered Rapid IV push - Half life of 10 seconds
SA of adenosine Brief asystole
Contraindications for all antidysrhythmics Drug allergy, AV block (2nd/3rd degree), bundle branch block, cardiogenic shock, sick sinus syndrome, and concurrent use of other antidysrhythmics.
What effect can all antidysrhythmic drugs cause Induce ddysrhythmias
What ECG monitoring is a concern with antidysrhythmic use? Prolonged QT interval - It can lead to torsades de pointes, a potentially fatal ventricular arrhythmia.
Created by: ahgecas25
 

 



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