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Exam 4
| Question | Answer |
|---|---|
| Muscle System Functions | movement, protect, maintain posture, valves, stabilizes joints, control pupil size, heat (contract), & goosebumps |
| Epimysium | sheath of dense, irr. CT covering the entire muscle |
| Perimysium | middle layer surrounding fascicle |
| Endomysium | A thin CT of collagen & reticular fibers surrounding each muscle fiber/cell |
| Skeletal Muscle | made out of muscle fascicles |
| Muscle Fibers | made out of myofibrils |
| Smooth Reticulum (SR) | smooth ER that stores, releases, & retrieve Ca++ |
| T-tubules | sarcolemma extensions into deep of the muscle fiber |
| Terminal Cisternae | SR that adjacent to T tubule |
| Triad | 2 terminal cistenae |
| I band | light band |
| MT features | Excitability, Elasticity, Extensibility, & Contractibility |
| Excitability | sends an electrical wave (action potential along the entire length of membrane) |
| Extensibility | stretch/expand |
| Elasticity | return back to its original length |
| Contractibility | pull on attachment points & shorten with force |
| Neuromuscular Junction | site where a motor neuron's terminal meets the muscle fibers |
| NMJ 1st step | neural action potential arrives @ NMJ |
| NMJ 2nd step | Axon releases neurotransmitter ACh |
| NMJ 3rd step | ACh diffuse to synaptic cleft & bind to ACh receptors at motor end plate |
| NMJ 4th step | Depolarization: Na+ channels open (end plate potential) and Na come in to the muscle |
| NMJ 5th step | triggers voltage-gated channel Na+ channels to open along the Sarcolemma, creating a muscle action potential that spread across the entire muscle fiber |
| NMJ 6th step | The action potential travels along down the T-tubules, reaching the SR |
| NMJ 7th step | SR release Ca++ from voltage gated channels into the sarcoplasm to start contraction |
| NMJ 8th step | The enzyme acetylcholinesterase (AChE) breaks down ACh so the muscle doesn’t stay contracted. |
| NMJ 9th step | repolarization |
| Muscle Fiber Contraction | When Ca++ is released from SR, it binds to troponin, Myosin heads attach. When ATP binds, it detach from action, and process is repeat |
| Sarcomere | smallest contractile unit in the muscle fiber |
| Motor Signal | signal for contraction to muscle |
| Contraction | release Ca++ from SR |
| Motor Unit | Both neuron & the muscle fibers it innervate (deliver the signals) |
| Motor neuron | carry the motor signal; can send the same signal for multiple muscles |
| Neuromuscular Junction | connection between the motor neuron & muscle |
| Tropomyosin | acts as the physical barrier between actin and myosin |
| ATP | needed to break the cross-bridge |
| Power stroke | Myosin pulls actin towards the M line |
| Power stroke | When ADP runs out, Myosin rapidly snaps back to its default position |
| Ca++ pump | move Ca++ back to SR |
| Muscle Twitch | Latent (Excitation) Period , Contraction Period, & Relaxation Period |
| Muscle Twitch | one contraction from one action potential |
| Latent period | time needed to open Na+ gate @ motor-end plate generate ATP, motive it down to T-tubue & relaxes Ca++ ions; AP is being propagated along the Sarcolemma & Ca++ is being released from the SR (5mm sec) |
| Contraction period | Cross-bridge cycle (20mm sec) |
| Relaxation period | Time needed to pump Ca++ back to SR |
| ATP | pump Ca++ back to SR |
| ATP | Na+/K+ pump |
| Creatine Phosphate | Fast way to produce ATP; short lasting (40 sec) & emergency use |
| Aerobic Respiration | require O2, uses glucose, fat/lipids & proteins to generate ATP; 1 glucose - 32 ATP; takes very long time |
| Anaerobic Respiration | works in low O2 conditions; only use glucose; 1 glucose - 2 ATP; Fast in producing ATP but unsustainable |
| Excitation | Ca++ out of the SR |
| Relaxation | Ca+ pump move Ca++ back to SR; Troponin restore its shape & Tropomyosin blocks myosin from actin |
| MP Depolarization | Contraction; Na+ enter; inside is less negative/positive |
| MP Repolarization | Relaxation; K+ exit; inside goes back to negative |
| Vesicles | inside the axon terminals; contains Acetylcholine ACh |
| Na+ gated channels | rest on the Sarcolemma |
| Ca++ gated channels | rest on the axon terminal |
| MP at rest | + out & - in; Na+ out & K+ in; -70 mV |
| Sliding Filament Model | Myosin pulls the actin toward the M line during contraction |