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Line of Defense

Bio205 Unit 3 (PC)

TermDefinition
Skin (Epidermis) 1st Physical - Blocks entry of microbe
Mucus 1st Physical - Sticky secretion that traps microbes
Saliva (Lysozyme) 1st Chemical - Enzyme that breaks down bacterial cell wall
Resident microbes 1st Physical/ Chemical - Physically blocks attachment and chemically beneficial microbe that compete with pathogen
Mucous membranes (epithelial cells) 1st Physical - Traps/ blocks entry
Sebum (oil) 1st Physical/ Chemical - Physically flushes out and chemically fatty acids in oil lower Ph
Cilia 1st Physical - sweeps away microbes trapped in mucus
Sweat (salt) 1st Physical/ Chemical - Physically flushes out and chemically discourages microbial growth (salt sucks)
Interferon (IFN) (virally) 1st Chemical from infected cells and 2nd macrophages - Signals neighboring cells to resist viral infections
Eosinophils 2nd Non-specific immune cell - Involved in parasitic infections and some allergic responses
Complement 2nd Non-specific chemical - C3b (opsonization), C3a+5a (phagocytosis- attracts immune cells and inflammation), C5-9 (Membrane Attack Complex)
Fever 2nd Non-specific process - Raises body temperature to inhibit pathogen growth
Macrophages (APC) 2nd Non-specific Immune cell - Engulfs microbes and presents antigens to T cells
Inflammation 2nd Non-specific process - Recruits immune cells and increases vascular permeability
IL-1 2nd chemical - Cytokine that induces fever and inflammation
Phagocytosis 2nd Non-specific process - Engulfing and digesting microbes
Neutrophils 2nd Non-specific Immune cell - rapidly phagocytoses bacteria
Basophils (in blood) 2nd Non-specific Immune cell -Releases histamine during allergic responses
MHC II 2nd-3rd - Displays foreign antigens to helper T cells
Plasma B cells 3rd specific cell - Produces antibodies specific to antigens
Th1 CD4+ T cells 3rd specific cell - Activates memory T cells and Cytotoxic CD8+ T cells
IgE 3rd Specific chemical - Causes allergic reactions and defends against parasites
Memory B cells 3rd Specific cell - Remembers microbe
IgG 3rd Specific chemical - Provides long-term immunity, can cross placenta
Th2 CD4+ T cells 3rd Specific cell - Activates memory B cells and plasma B cells
IgA 3rd Specific chemical - Antibody found in mucosal secretion (Provides passive immunity to infant's via breast milk)
CD8+ cytotoxic T cells 3rd Specific cell - Kills infected cells via perforins and granzymes (virus, cancer, transplant)
Antibodies 3rd Specific chemical - Proteins that bind to antigens (neutralizes, opsonizes, etc)
IgM 3rd Specific chemical - main first responder (large)
Suppressor T cells 3rd Immune cell - Regulate and suppress immune responses
MHC I 3rd Displays self/cancerous antigens to CD8+ T cells
Created by: Andreuh
 

 



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