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Line of Defense
Bio205 Unit 3 (PC)
| Term | Definition |
|---|---|
| Skin (Epidermis) | 1st Physical - Blocks entry of microbe |
| Mucus | 1st Physical - Sticky secretion that traps microbes |
| Saliva (Lysozyme) | 1st Chemical - Enzyme that breaks down bacterial cell wall |
| Resident microbes | 1st Physical/ Chemical - Physically blocks attachment and chemically beneficial microbe that compete with pathogen |
| Mucous membranes (epithelial cells) | 1st Physical - Traps/ blocks entry |
| Sebum (oil) | 1st Physical/ Chemical - Physically flushes out and chemically fatty acids in oil lower Ph |
| Cilia | 1st Physical - sweeps away microbes trapped in mucus |
| Sweat (salt) | 1st Physical/ Chemical - Physically flushes out and chemically discourages microbial growth (salt sucks) |
| Interferon (IFN) (virally) | 1st Chemical from infected cells and 2nd macrophages - Signals neighboring cells to resist viral infections |
| Eosinophils | 2nd Non-specific immune cell - Involved in parasitic infections and some allergic responses |
| Complement | 2nd Non-specific chemical - C3b (opsonization), C3a+5a (phagocytosis- attracts immune cells and inflammation), C5-9 (Membrane Attack Complex) |
| Fever | 2nd Non-specific process - Raises body temperature to inhibit pathogen growth |
| Macrophages (APC) | 2nd Non-specific Immune cell - Engulfs microbes and presents antigens to T cells |
| Inflammation | 2nd Non-specific process - Recruits immune cells and increases vascular permeability |
| IL-1 | 2nd chemical - Cytokine that induces fever and inflammation |
| Phagocytosis | 2nd Non-specific process - Engulfing and digesting microbes |
| Neutrophils | 2nd Non-specific Immune cell - rapidly phagocytoses bacteria |
| Basophils (in blood) | 2nd Non-specific Immune cell -Releases histamine during allergic responses |
| MHC II | 2nd-3rd - Displays foreign antigens to helper T cells |
| Plasma B cells | 3rd specific cell - Produces antibodies specific to antigens |
| Th1 CD4+ T cells | 3rd specific cell - Activates memory T cells and Cytotoxic CD8+ T cells |
| IgE | 3rd Specific chemical - Causes allergic reactions and defends against parasites |
| Memory B cells | 3rd Specific cell - Remembers microbe |
| IgG | 3rd Specific chemical - Provides long-term immunity, can cross placenta |
| Th2 CD4+ T cells | 3rd Specific cell - Activates memory B cells and plasma B cells |
| IgA | 3rd Specific chemical - Antibody found in mucosal secretion (Provides passive immunity to infant's via breast milk) |
| CD8+ cytotoxic T cells | 3rd Specific cell - Kills infected cells via perforins and granzymes (virus, cancer, transplant) |
| Antibodies | 3rd Specific chemical - Proteins that bind to antigens (neutralizes, opsonizes, etc) |
| IgM | 3rd Specific chemical - main first responder (large) |
| Suppressor T cells | 3rd Immune cell - Regulate and suppress immune responses |
| MHC I | 3rd Displays self/cancerous antigens to CD8+ T cells |