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Anatomy
Heart Anatomy and Development
| Question | Answer |
|---|---|
| What are the three major plasma proteins? | Albumin – maintains osmotic pressure Globulins – antibodies & transport proteins Fibrinogen – clot formation |
| What is the structure of red blood cells (RBCs)? | Biconcave discs No nucleus or organelles Flexible membrane Packed with hemoglobin |
| Name other key solutes in blood plasma | Electrolytes (Na⁺, K⁺, Ca²⁺), nutrients (glucose, amino acids), gases (O₂/CO₂), hormones, and metabolic wastes (urea, bilirubin) |
| What is hemoglobin and what does it do | A protein with 4 globin chains and 4 heme groups, each containing iron. It binds and transports oxygen (and some CO₂). |
| How are white blood cells (WBCs) classified? | Granulocytes: neutrophils, eosinophils, basophils Agranulocytes: lymphocytes, monocytes |
| What are neutrophils and their function? | Most abundant WBC. Phagocytosis of bacteria. First responders during infection. |
| What are eosinophils and their function? | Fight parasites and participate in allergic reactions. |
| What are basophils and their function? | Release histamine and heparin → inflammation & anticoagulation. |
| What are lymphocytes and their function? | B-cells (antibodies), T-cells (cell-mediated immunity), NK cells (destroy abnormal cells). |
| What are monocytes and their function? A: | What are monocytes and their function? A: |
| Describe the structure of platelets | Fragments of megakaryocytes; contain granules with clotting factors; small, disc-shaped; no nucleus |
| What is the function of platelets? | Start blood clotting, form platelet plug, release factors that stabilize clots. |
| Presence of A and/or B antigens on RBCs | |
| Why is type AB the universal recipient? | Has no antibodies against A or B antigens. |
| What determines the Rh blood group? | Presence (Rh⁺) or absence (Rh⁻) of the D antigen on RBCs. |
| Why is Rh important in pregnancy? | Rh⁻ mother carrying Rh⁺ fetus → risk of hemolytic disease of the newborn |
| Where is the heart located in the body? | In the thoracic cavity, in the mediastinum, between the lungs, behind the sternum, above the diaphragm. |
| How is the heart positioned? | Apex: left/inferior Base: superior/right 2/3 of heart left of midline |
| What are the atrioventricular (AV) valves? | Tricuspid (RA → RV) Mitral/Bicuspid (LA → LV) |
| Name the four heart chambers | Right atrium, right ventricle, left atrium, left ventricle. |
| What are the semilunar valves? | Pulmonary (RV → pulmonary trunk) Aortic (LV → aorta) |
| Describe the internal anatomy of the ventricles | Thick myocardium, papillary muscles, chordae tendineae, interventricular septum. |
| Describe the major external features of the heart | Apex, base, coronary sulcus, interventricular sulci, auricles, great vessels |
| What are the major coronary arteries? | Left coronary artery (LCA) → LAD & circumflex Right coronary artery (RCA) → marginal & posterior interventricular |
| What are the major coronary veins? | Great, middle, small cardiac veins → coronary sinus → right atrium |
| Great, middle, small cardiac veins → coronary sinus → right atrium | Ductus venosus Foramen ovale Ductus arteriosus |
| What is the foramen ovale and what does it become? | RA → LA opening; becomes fossa ovalis after birth. |
| What is the ductus arteriosus and what does it become? | Pulmonary trunk → aorta; becomes ligamentum arteriosum |
| When does the fetal heart start beating? | Around week 4 of development. |
| Why does fetal circulation bypass the lungs? | Lungs are collapsed and nonfunctional until birth; gas exchange occurs in the placenta. |