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Psych 3.3
| Question | Answer |
|---|---|
| Affective blunting | Reduced or constricted affect |
| Apathy | Expressed anhedonia, decreased interest in activities or beliefs that would otherwise be interesting |
| Alogia | Poverty of speech, reduction in speech |
| Constricted | Reduced in range or intensity, i.e showing only sadness or anger and nothing else |
| ANosognosia | The inability to recognize that one is ill |
| Affective sx | Altered experience and expression of emotions. Mood may change rapidly. |
| Should you debate delusional content? | Never debate delusional content |
| Name the first generation antipsychotics | Haloperidol, fluphenazine, chlorpromazine, decanoate |
| Side effects of first generation antipsychotics | Can cause anticholinergic side effects and extrapyramidal effects, along with tardive dyskinesia, weight gain, and sexual dysfunction. |
| What are the second generation antipsychotics? | ripiprazole, risperidone, clozapine, olanzapine, anything that ends in pine or one. |
| Second generation antipsychotics MOA, what it treats, and sx | Serotonin and dopamine receptor antagonists, treats both positive and negative symptoms, has minimal to no EPS or tardive dyskinesia. Tendency for metabolic syndrome. |
| What is the most used drug for resistant schizophrenia? | Clozapine |
| What are third generation antipsychotics? | Aripiprazole, bexipiprazole, cariprazine. |
| Anticholinergic toxicity side effects | Reduced bowel peristalsis, can lead to obstruction, urinary retention, hyperpyrexia without diaphoresis, and delirium. |
| Side effects of QT prolongation caused by antipsychotics | Tachycardia, syncope, seizures, sudden death. Liver impairment occurs in the first few weeks of therapy. |
| Extrapyramidal side effects (Mild) | Akinesia, akathisa, pseudoparkinsonism. |
| What is akathisa? | Restlessness |
| Mild extrapyramidal side effects can be treated by | Benztropine or diphenhydramine |
| Extrapyramidal side effects (Severe) | Acute dystonia, oculogyric crisis. |
| Severe extrapyramidal side effects should be treated by | IV benztropine |
| What is the presentation, risks, scale used for tardive dyskinesia? | Presents as bizarre facial and tongue movements, can cause permanent damage to voluntary muscles, use the AIMS scale |
| Treatment of tardive dyskinesia | Valbenazine and deutetrabenazine |