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Patho Ch 40/41

Patho Exam 3

TermDefinition
Acute skin conditions -Bacterial or fungal infection -Contact with offending organism or allergen -Meds
Acute skin conditions can possibly transition to what? To chronic skin conditions, might not be able to be resolved
What can some inflammatory disorders be? Life threatening
Chronic skin conditions -Long term, may or may not resolve -Viral infection (takes long to control) -May or may not resolve
Where is there pain from damage? Pain from damage to first layer of the skin
What protects the body with acute skin disorders? Immune system and intact skin
What does impaired tissue integrity lead to? Immune response
Immune response from what will lead to lack of tissue integrity? From allergy and inflammation
What is itchiness related to? Histamine, do not know why the skin gets itchy tho
What does alterations in tissue perfusion lead to? Damage or necrosis
What is cellulitis? Diffuse painful inflammation of skin and subcutaneous layers induced by a bacterial infection that enters through a break in the skin
Examples of break in the skin that can cause cellulitis -Cut -Scrape -Burn -Surgical incision -Bug bite
What age population gets cellulitis? Adult population
Clinical manifestations of cellulitis -Painful, red, swollen area of skin: hot, tender to touch -Fever and chills -Vesicles, bullae, plaques -Tachycardia, hypotension, confusion, headache
What bacteria is seen with cellulitis? Staphylococcus bacteria
What is lymphadenitis with cellulitis? Inflammation of the lymphatic system
What is lymphangitis with cellulitis? Inflammation of the lymph nodes
What is impetigo? Superficial acute, highly contagious skin infection
Etiology and pathogenesis of cellulitis -Colonization facilitated by high temp, humidity, preexisting skin disorders -Recent antibiotic treatment
What age group gets impetigo? Young age (2-5 years old), more often in infants and young children
Why do we need to treat impetigo with abx? Highly contagious and spreads quick, cannot let kid go to daycare or park
What is furuncle? Extension of folliculitis or infection of sebaceous gland
Where does furuncle spread? Spreads down hair shaft through the follicle and into the dermis (bad odor)
What is carbuncle? Cluster of infected hair follicles
The cluster of carbuncle comes together to form what? Form lesion filled with pus, dead tissue, fluid (more than 2 sebaceous glands involved)
What is candidiasis? Infection of skin or mucous membranes with any species of Candida
What type of bacteria is most common with candidiasis? C. albicans most common
What moist areas do we find candidiasis? Mouth, throat, lungs, vagina, folds of skin, bowel
What type of condition is candidiasis? Usually secondary condition, allergy or bacterial infection that attracts fungus to the area
Where is candida normal? In skin and mucous membranes
What can cause infection with candida? Warmth, moisture, breaks in epidermis can cause infection
When is candida life threatening? If it enters the bloodstream!
Clinical manifestations of candidiasis -Thrush -Vaginal -Balanitis -Diaper Rash
What is thrush? White covering of tongue, mouth, throat
What is vaginal yeast infection? Itching, foul odor, white discharge
What is balanitis? Flattened pustules, edema, burning, tenderness
What is diaper rash? Dark red patches in skin folds, fluid-filled spots
What is tinea? Contagious infection by different types of fungus (just induces pain)
What are superficial infections of tinea called? Called dermatophytoses
What are tinea infections named by? Location on the body
Tinea pedis -Athletes foot -Itching, scaling, blisters between the toes
Tinea curis -Jock itch -A rash in the groin area
Tinea capitis -Ringworm of the scalp -Itchy, red patches, hair loss
Tinea corporis -Ringworm on the body -Ring-shaped rash
Tinea versicolor -Discolored -Scaly -Dry patches on the skin
What is necrotizing fasciitis known as? Flesh-eating disorder
Necrotizing fasciitis is a rapidly spreading infection caused by what? Aerobic and anaerobic bacteria (very hard to treat)
What does necrotizing fasciitis start from? Contagious ulcer, wound, untreated skin infection, complication of surgery, abscess
What is there an occlusion of with necrotizing fasciitis? Small subcutaneous vessels, tissue ischemia, infarction, necrosis
When is there an increased incidence with necrotizing fasciitis? Inc incidence with any autoimmune disease
What is steven-johnsons syndrome? Rare disorder of the skin and mucous membranes
What does cell death cause in steven-johnsons syndrome? Epidermis to separate from the dermis
Etiology of steven johnsons syndrome -More than 200 meds -Infectious causes -Delayed hypersensitive reaction
Clinical manifestations of steven johnsons syndrome -Flu-like symptoms -Symmetric burning rash: red, purple target lesions (in skin)
What can steven johnsons progress into? Toxic epidermal necrolysis (TEN)
What is toxic epidermal necrolysis? Inflammation of skin caused by poison
What is TEN with spots? Widespread with detachment of epidermis, erosion
TEN with spots is what percent of the body surface? More than 30% of body surface area
What is TEN without spots? Widespread with erythema, no lesions
TEN without spots is what percent of the body surface? More than 10% of body surface area
Etiology of TEN -Reactions to drugs -Bacterial infection -Malignancy (anything linked with cancer) -Graft versus host disease (bone marrow transplant) -Vaccinations
TEN clinical manifestations -Flu-like symptoms -Rash, large blisters in center -Rash ruptures -Skin peels off
Examples of common causative organisms for chronic viral skin infections -Herpes simplex virus -Varicella-zoster virus -Human papillomavirus
When is herpes simplex virus type 1 usually contracted? During childhood
What do recurrences persist into with HSV-1? Into old age, always in the body and occur throughout adulthood
What is the most common HSV-1 infection? Herpes labialis (lips, cold sores)
What is affected with herpetic keratitis? Eye
What is affected with herpetic whitlow? Digits or hands
What is affected with herpetic gladiatorum? Torso of wrestlers
What is affected with herpetic sycosis? Beard follicles, hair follicles
What does herpes simplex virus type 2 cause? -Most sexually transmitted angiogenital herpes -Cold sores
What are sexually transmitted angiogenital herpes? Lesions on genitals, perineum, anus (openings)
What is less common with HSV-2 but still can happen? Cold sores
How is HSV-2 likely to be contracted? Via sexual contact
Who typically contracts HSV-2? Adolescence or young adulthood
HSV-2 is the ____ most common US sexually transmitted infection Fifth
There is 1 in how many adolescents and adults of both genders affected with HSV-2? 1 in 6
HSV: how does the virus enter the skin or mucous membrane? Via a microscopic tear
HSV: where does the virus travel? Sensory root ganglion
HSV: what does the virus become of the ganglion? Virus becomes dormant and permanent resident of ganglion
HSV: what is triggered? Cell mediated immune system is triggered, viral activation occurs
HSV: where does the virus travel from? Travels from neuron to skin innervated by the neuron
HSV: what cells does the virus enter? Virus enters dermal and epidermal cells
HSV: what does viral replication cause? Recurrent rash outbreak, manifests at the surface
HSV clinical manifestations -Asymptomatic herpes, mild fever -Prodrome: fever or flu-like symptoms -Red, swollen area of skin or mucous membrane develops -Eruption of painful vesicles -Regional lymph nodes swell
What do lesions do in HSV? Lesions open and form painful ulcers that crust and begin healing
What may primary genital herpes cause? May cause dysuria (pain peeing) and urinary retention, especially in women
Created by: mmc238
 

 



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