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Patho Ch 40/41
Patho Exam 3
| Term | Definition |
|---|---|
| Acute skin conditions | -Bacterial or fungal infection -Contact with offending organism or allergen -Meds |
| Acute skin conditions can possibly transition to what? | To chronic skin conditions, might not be able to be resolved |
| What can some inflammatory disorders be? | Life threatening |
| Chronic skin conditions | -Long term, may or may not resolve -Viral infection (takes long to control) -May or may not resolve |
| Where is there pain from damage? | Pain from damage to first layer of the skin |
| What protects the body with acute skin disorders? | Immune system and intact skin |
| What does impaired tissue integrity lead to? | Immune response |
| Immune response from what will lead to lack of tissue integrity? | From allergy and inflammation |
| What is itchiness related to? | Histamine, do not know why the skin gets itchy tho |
| What does alterations in tissue perfusion lead to? | Damage or necrosis |
| What is cellulitis? | Diffuse painful inflammation of skin and subcutaneous layers induced by a bacterial infection that enters through a break in the skin |
| Examples of break in the skin that can cause cellulitis | -Cut -Scrape -Burn -Surgical incision -Bug bite |
| What age population gets cellulitis? | Adult population |
| Clinical manifestations of cellulitis | -Painful, red, swollen area of skin: hot, tender to touch -Fever and chills -Vesicles, bullae, plaques -Tachycardia, hypotension, confusion, headache |
| What bacteria is seen with cellulitis? | Staphylococcus bacteria |
| What is lymphadenitis with cellulitis? | Inflammation of the lymphatic system |
| What is lymphangitis with cellulitis? | Inflammation of the lymph nodes |
| What is impetigo? | Superficial acute, highly contagious skin infection |
| Etiology and pathogenesis of cellulitis | -Colonization facilitated by high temp, humidity, preexisting skin disorders -Recent antibiotic treatment |
| What age group gets impetigo? | Young age (2-5 years old), more often in infants and young children |
| Why do we need to treat impetigo with abx? | Highly contagious and spreads quick, cannot let kid go to daycare or park |
| What is furuncle? | Extension of folliculitis or infection of sebaceous gland |
| Where does furuncle spread? | Spreads down hair shaft through the follicle and into the dermis (bad odor) |
| What is carbuncle? | Cluster of infected hair follicles |
| The cluster of carbuncle comes together to form what? | Form lesion filled with pus, dead tissue, fluid (more than 2 sebaceous glands involved) |
| What is candidiasis? | Infection of skin or mucous membranes with any species of Candida |
| What type of bacteria is most common with candidiasis? | C. albicans most common |
| What moist areas do we find candidiasis? | Mouth, throat, lungs, vagina, folds of skin, bowel |
| What type of condition is candidiasis? | Usually secondary condition, allergy or bacterial infection that attracts fungus to the area |
| Where is candida normal? | In skin and mucous membranes |
| What can cause infection with candida? | Warmth, moisture, breaks in epidermis can cause infection |
| When is candida life threatening? | If it enters the bloodstream! |
| Clinical manifestations of candidiasis | -Thrush -Vaginal -Balanitis -Diaper Rash |
| What is thrush? | White covering of tongue, mouth, throat |
| What is vaginal yeast infection? | Itching, foul odor, white discharge |
| What is balanitis? | Flattened pustules, edema, burning, tenderness |
| What is diaper rash? | Dark red patches in skin folds, fluid-filled spots |
| What is tinea? | Contagious infection by different types of fungus (just induces pain) |
| What are superficial infections of tinea called? | Called dermatophytoses |
| What are tinea infections named by? | Location on the body |
| Tinea pedis | -Athletes foot -Itching, scaling, blisters between the toes |
| Tinea curis | -Jock itch -A rash in the groin area |
| Tinea capitis | -Ringworm of the scalp -Itchy, red patches, hair loss |
| Tinea corporis | -Ringworm on the body -Ring-shaped rash |
| Tinea versicolor | -Discolored -Scaly -Dry patches on the skin |
| What is necrotizing fasciitis known as? | Flesh-eating disorder |
| Necrotizing fasciitis is a rapidly spreading infection caused by what? | Aerobic and anaerobic bacteria (very hard to treat) |
| What does necrotizing fasciitis start from? | Contagious ulcer, wound, untreated skin infection, complication of surgery, abscess |
| What is there an occlusion of with necrotizing fasciitis? | Small subcutaneous vessels, tissue ischemia, infarction, necrosis |
| When is there an increased incidence with necrotizing fasciitis? | Inc incidence with any autoimmune disease |
| What is steven-johnsons syndrome? | Rare disorder of the skin and mucous membranes |
| What does cell death cause in steven-johnsons syndrome? | Epidermis to separate from the dermis |
| Etiology of steven johnsons syndrome | -More than 200 meds -Infectious causes -Delayed hypersensitive reaction |
| Clinical manifestations of steven johnsons syndrome | -Flu-like symptoms -Symmetric burning rash: red, purple target lesions (in skin) |
| What can steven johnsons progress into? | Toxic epidermal necrolysis (TEN) |
| What is toxic epidermal necrolysis? | Inflammation of skin caused by poison |
| What is TEN with spots? | Widespread with detachment of epidermis, erosion |
| TEN with spots is what percent of the body surface? | More than 30% of body surface area |
| What is TEN without spots? | Widespread with erythema, no lesions |
| TEN without spots is what percent of the body surface? | More than 10% of body surface area |
| Etiology of TEN | -Reactions to drugs -Bacterial infection -Malignancy (anything linked with cancer) -Graft versus host disease (bone marrow transplant) -Vaccinations |
| TEN clinical manifestations | -Flu-like symptoms -Rash, large blisters in center -Rash ruptures -Skin peels off |
| Examples of common causative organisms for chronic viral skin infections | -Herpes simplex virus -Varicella-zoster virus -Human papillomavirus |
| When is herpes simplex virus type 1 usually contracted? | During childhood |
| What do recurrences persist into with HSV-1? | Into old age, always in the body and occur throughout adulthood |
| What is the most common HSV-1 infection? | Herpes labialis (lips, cold sores) |
| What is affected with herpetic keratitis? | Eye |
| What is affected with herpetic whitlow? | Digits or hands |
| What is affected with herpetic gladiatorum? | Torso of wrestlers |
| What is affected with herpetic sycosis? | Beard follicles, hair follicles |
| What does herpes simplex virus type 2 cause? | -Most sexually transmitted angiogenital herpes -Cold sores |
| What are sexually transmitted angiogenital herpes? | Lesions on genitals, perineum, anus (openings) |
| What is less common with HSV-2 but still can happen? | Cold sores |
| How is HSV-2 likely to be contracted? | Via sexual contact |
| Who typically contracts HSV-2? | Adolescence or young adulthood |
| HSV-2 is the ____ most common US sexually transmitted infection | Fifth |
| There is 1 in how many adolescents and adults of both genders affected with HSV-2? | 1 in 6 |
| HSV: how does the virus enter the skin or mucous membrane? | Via a microscopic tear |
| HSV: where does the virus travel? | Sensory root ganglion |
| HSV: what does the virus become of the ganglion? | Virus becomes dormant and permanent resident of ganglion |
| HSV: what is triggered? | Cell mediated immune system is triggered, viral activation occurs |
| HSV: where does the virus travel from? | Travels from neuron to skin innervated by the neuron |
| HSV: what cells does the virus enter? | Virus enters dermal and epidermal cells |
| HSV: what does viral replication cause? | Recurrent rash outbreak, manifests at the surface |
| HSV clinical manifestations | -Asymptomatic herpes, mild fever -Prodrome: fever or flu-like symptoms -Red, swollen area of skin or mucous membrane develops -Eruption of painful vesicles -Regional lymph nodes swell |
| What do lesions do in HSV? | Lesions open and form painful ulcers that crust and begin healing |
| What may primary genital herpes cause? | May cause dysuria (pain peeing) and urinary retention, especially in women |