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Immune System
| Question | Answer |
|---|---|
| Innate Immunity | immunity that's always present |
| First line of defense | barriers like the skin |
| Second line of defense | phagocytic cells that ingest foreign cells |
| Phagocytes meaning | large cells that engulf pathogens |
| What are pathogens? | Agents that cause disease |
| B cells | produce antibodies, has unlimited diversity |
| T cells (in general) | protects the body from infection by identifying and killing infected cells |
| T helper cells (analogy: commanders) | activate other immune cells and help coordinate an immune response |
| T cytotoxic cells (the killers) | directly destroy infected cells |
| T regulatory cells | suppress immune response to prevent autoimmunity |
| What are antibodies | proteins that bind specifically to substances identified by immune system (bind to antigen) |
| What type of cells are antibodies produced by? | B cells (very specific antibody for a specific antigen) |
| What happens when an antibody binds to an antigen? | The coding region changes |
| What is clonal selection? | when new virus enters the body, B cell must know that antigen is present. This causes the B cell to go through the cell cycle rapidly and make more antibodies |
| What are the 2 pathways these B cells can go? | 1) plasma cells that secrete more of the antibody 2) non-secreting memory cells that divide at a slow rate in case you get reinfected |
| What is clonal deletion | kills cells off (opposite of clonal selection) |
| Primary Response | when antigen is introduced "naive" lymphocytes proliferate to produce the plasma "effector" cells and memory cells |
| Secondary response | when an antigen is encountered again, the memory cells are what proliferates and launches an army of plasma and T cells |
| Virus | infective agent that typically consists of a nucleic acid molecule in a protein coat, able to multiply only within the living cells of a host. |
| How do viruses infect? | they need to hijack into the cell to be able to replicate and make new virus cells |
| Why do virus exist? | they're good at existing. they can evolve to invade immune response |