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exam 4

QuestionAnswer
Kidneys filter blood to make what? Urine
What wastes do the kidneys remove? Urea, uric acid, creatinine
What balances do the kidneys regulate? Water, electrolytes, acid-base, and blood pressure
Which hormone from kidneys raises blood pressure? Renin
Which hormone from kidneys increases RBC production? Erythropoietin
Which vitamin do kidneys activate? Vitamin D
Main organs of the urinary system? Kidneys, ureters, bladder, urethra
Pathway of filtrate through nephron? Bowman’s capsule → PCT → Loop → DCT → Collecting duct
Two types of nephrons? Cortical and juxtamedullary
Which nephrons produce concentrated urine? Juxtamedullary nephrons
What are the three steps of urine formation? Filtration, reabsorption, secretion
Normal GFR value? About 125 mL/min
Effect of afferent arteriole dilation on GFR? Increases GFR
Effect of afferent arteriole constriction on GFR? Decreases GFR
What is autoregulation of GFR? Maintaining constant GFR despite BP changes
What are the two autoregulatory mechanisms? Myogenic mechanism and tubuloglomerular feedback
Which hormone retains sodium and water? Aldosterone
Which hormone retains water only? ADH
Which hormone increases urine output? ANP
What creates the medullary salt gradient? Countercurrent multiplier in the nephron loop
What maintains the salt gradient? Countercurrent exchange in the vasa recta
Normal urine pH? Around 6
Normal urine should NOT contain? Protein, glucose, blood cells
Muscle that contracts the bladder? Detrusor muscle
Internal urethral sphincter control? Involuntary (smooth muscle)
External urethral sphincter control? Voluntary (skeletal muscle)
Female urethra length vs male? Female shorter → higher UTI risk
What triggers micturition reflex? Bladder stretch receptors
Main fluid compartments? Intracellular and extracellular
Most abundant intracellular cation? Potassium (K⁺)
Most abundant extracellular cation? Sodium (Na⁺)
Fluid inside cells? Intracellular fluid (ICF)
Fluid outside cells? Extracellular fluid (ECF)
Two parts of ECF? Interstitial fluid and plasma
What is hydrostatic pressure? Force pushing water out of a compartment
What is osmotic pressure? Force pulling water into a compartment
What is tonicity? Relative solute concentration affecting water movement
What is obligatory water loss? Minimal urine/fecal loss required daily
What is insensible water loss? Evaporation from skin and breathing
What detects high plasma osmolarity? Osmoreceptors in hypothalamus
What hormone conserves water in dehydration? ADH
Dehydration causes what electrolyte change? Increased Na⁺ concentration
Overhydration causes what problem? Low Na⁺ (hyponatremia) and cell swelling
Main function of sodium ion? Maintains fluid balance and nerve function
Main function of potassium ion? Resting membrane potential and muscle function
Main function of calcium ion? Muscle contraction, nerve signaling, clotting
Main function of phosphate ion? Bone structure, ATP, DNA/RNA
Main function of bicarbonate ion? Buffer to maintain pH
Main function of chloride ion? Works with Na⁺ for osmotic balance, stomach acid
Hypernatremia cause? Dehydration
Hyponatremia cause? Overhydration or excess ADH
Hyperkalemia effect? Cardiac arrhythmias, weakness
Hypokalemia effect? Muscle cramps, irregular heart rhythm
Hypercalcemia effect? Decreased excitability, kidney stones
Hypocalcemia effect? Tetany, muscle spasms
Relationship between calcium and phosphate? Inversely regulated
Normal blood pH range? 7.35 – 7.45
Volatile acid example? Carbonic acid (H₂CO₃)
Fixed acid examples? Lactic acid, ketone bodies
Most important ECF buffer system? Carbonic acid–bicarbonate system
Main ICF and kidney buffer system? Phosphate buffer system
Most abundant buffer overall? Protein buffer system (e.g., hemoglobin)
Effect of hypoventilation on pH? CO₂ ↑ → pH ↓ (acidosis)
Effect of hyperventilation on pH? CO₂ ↓ → pH ↑ (alkalosis)
How do kidneys raise pH? Secrete H⁺ and reabsorb HCO₃⁻
Respiratory compensation fixes what type of imbalance? Metabolic pH problems
Renal compensation fixes what type of imbalance? Respiratory pH problems
Respiratory acidosis cause? Hypoventilation → CO₂ retention
Respiratory alkalosis cause? Hyperventilation → CO₂ loss
Metabolic acidosis cause? Low HCO₃⁻ from DKA, diarrhea, renal failure
Metabolic alkalosis cause? High HCO₃⁻ from vomiting or antacids
Compensation for metabolic acidosis? Hyperventilation (Kussmaul breathing)
Compensation for metabolic alkalosis? Hypoventilation
Compensation for respiratory acidosis? Kidneys ↑ HCO₃⁻ retention
Compensation for respiratory alkalosis? Kidneys ↓ HCO₃⁻ reabsorption
Created by: user-1996379
 

 



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