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exam 4
| Question | Answer |
|---|---|
| Kidneys filter blood to make what? | Urine |
| What wastes do the kidneys remove? | Urea, uric acid, creatinine |
| What balances do the kidneys regulate? | Water, electrolytes, acid-base, and blood pressure |
| Which hormone from kidneys raises blood pressure? | Renin |
| Which hormone from kidneys increases RBC production? | Erythropoietin |
| Which vitamin do kidneys activate? | Vitamin D |
| Main organs of the urinary system? | Kidneys, ureters, bladder, urethra |
| Pathway of filtrate through nephron? | Bowman’s capsule → PCT → Loop → DCT → Collecting duct |
| Two types of nephrons? | Cortical and juxtamedullary |
| Which nephrons produce concentrated urine? | Juxtamedullary nephrons |
| What are the three steps of urine formation? | Filtration, reabsorption, secretion |
| Normal GFR value? | About 125 mL/min |
| Effect of afferent arteriole dilation on GFR? | Increases GFR |
| Effect of afferent arteriole constriction on GFR? | Decreases GFR |
| What is autoregulation of GFR? | Maintaining constant GFR despite BP changes |
| What are the two autoregulatory mechanisms? | Myogenic mechanism and tubuloglomerular feedback |
| Which hormone retains sodium and water? | Aldosterone |
| Which hormone retains water only? | ADH |
| Which hormone increases urine output? | ANP |
| What creates the medullary salt gradient? | Countercurrent multiplier in the nephron loop |
| What maintains the salt gradient? | Countercurrent exchange in the vasa recta |
| Normal urine pH? | Around 6 |
| Normal urine should NOT contain? | Protein, glucose, blood cells |
| Muscle that contracts the bladder? | Detrusor muscle |
| Internal urethral sphincter control? | Involuntary (smooth muscle) |
| External urethral sphincter control? | Voluntary (skeletal muscle) |
| Female urethra length vs male? | Female shorter → higher UTI risk |
| What triggers micturition reflex? | Bladder stretch receptors |
| Main fluid compartments? | Intracellular and extracellular |
| Most abundant intracellular cation? | Potassium (K⁺) |
| Most abundant extracellular cation? | Sodium (Na⁺) |
| Fluid inside cells? | Intracellular fluid (ICF) |
| Fluid outside cells? | Extracellular fluid (ECF) |
| Two parts of ECF? | Interstitial fluid and plasma |
| What is hydrostatic pressure? | Force pushing water out of a compartment |
| What is osmotic pressure? | Force pulling water into a compartment |
| What is tonicity? | Relative solute concentration affecting water movement |
| What is obligatory water loss? | Minimal urine/fecal loss required daily |
| What is insensible water loss? | Evaporation from skin and breathing |
| What detects high plasma osmolarity? | Osmoreceptors in hypothalamus |
| What hormone conserves water in dehydration? | ADH |
| Dehydration causes what electrolyte change? | Increased Na⁺ concentration |
| Overhydration causes what problem? | Low Na⁺ (hyponatremia) and cell swelling |
| Main function of sodium ion? | Maintains fluid balance and nerve function |
| Main function of potassium ion? | Resting membrane potential and muscle function |
| Main function of calcium ion? | Muscle contraction, nerve signaling, clotting |
| Main function of phosphate ion? | Bone structure, ATP, DNA/RNA |
| Main function of bicarbonate ion? | Buffer to maintain pH |
| Main function of chloride ion? | Works with Na⁺ for osmotic balance, stomach acid |
| Hypernatremia cause? | Dehydration |
| Hyponatremia cause? | Overhydration or excess ADH |
| Hyperkalemia effect? | Cardiac arrhythmias, weakness |
| Hypokalemia effect? | Muscle cramps, irregular heart rhythm |
| Hypercalcemia effect? | Decreased excitability, kidney stones |
| Hypocalcemia effect? | Tetany, muscle spasms |
| Relationship between calcium and phosphate? | Inversely regulated |
| Normal blood pH range? | 7.35 – 7.45 |
| Volatile acid example? | Carbonic acid (H₂CO₃) |
| Fixed acid examples? | Lactic acid, ketone bodies |
| Most important ECF buffer system? | Carbonic acid–bicarbonate system |
| Main ICF and kidney buffer system? | Phosphate buffer system |
| Most abundant buffer overall? | Protein buffer system (e.g., hemoglobin) |
| Effect of hypoventilation on pH? | CO₂ ↑ → pH ↓ (acidosis) |
| Effect of hyperventilation on pH? | CO₂ ↓ → pH ↑ (alkalosis) |
| How do kidneys raise pH? | Secrete H⁺ and reabsorb HCO₃⁻ |
| Respiratory compensation fixes what type of imbalance? | Metabolic pH problems |
| Renal compensation fixes what type of imbalance? | Respiratory pH problems |
| Respiratory acidosis cause? | Hypoventilation → CO₂ retention |
| Respiratory alkalosis cause? | Hyperventilation → CO₂ loss |
| Metabolic acidosis cause? | Low HCO₃⁻ from DKA, diarrhea, renal failure |
| Metabolic alkalosis cause? | High HCO₃⁻ from vomiting or antacids |
| Compensation for metabolic acidosis? | Hyperventilation (Kussmaul breathing) |
| Compensation for metabolic alkalosis? | Hypoventilation |
| Compensation for respiratory acidosis? | Kidneys ↑ HCO₃⁻ retention |
| Compensation for respiratory alkalosis? | Kidneys ↓ HCO₃⁻ reabsorption |