The effects produced by one or both of the drugs may be increased. ex aspirin + acetaminophen = more pain relief than either alone, but no unexpected boost 1+1=2

A drug-drug interaction or drug-food interaction that decreases or blocks the effect of another drug. 1 + 1 = 0 ⮚For example: Naloxone + opioid analgesics (e.g., morphine)

Drug-disease contraindication

Drug administration should be avoided because it may worsen the patient’s medical condition

Drug-drug interaction

Effect that occurs when two or more drugs are administered at the same time.

Drug-food interaction

Altered drug response that occurs when a drug is administered with certain foods.

The process where one drug, or a food, increases the effects of another drug yet does not produce any effect when administered alone. 1 + 0 = 2 for example: griseofulvin (antifungal) + fatty foods

Result when two drugs administered together produce effects that are greater than would be produced if either drug were administered alone.. ex warfarin + aspirin (increased bleeding) 1+1 =3

Therapeutic duplication

is the administration of multiple drugs that produce similar therapeutic effects and side effects, often from the same drug class

Bacteriostatic and bactericidal antiinfectives

⮚Interactions that decrease drug effects

“Azole” antifungals or fluoroquinolone antiinfectives and antacids

⮚Interactions that decrease drug effects

Penicillins and oral contraceptives

⮚Interactions that decrease drug effects

• Probenicid and penicillin • Alcohol and H2 receptor antagonists (e.g., cimetidine)

Interactions that increase drug effects

Atorvastatin and simavastatin—anticholesterol drugs—and grapefruit juice ⮚Dairy products and the antiinfective tetracycline ⮚Ferrous products (iron) and levothyroxine

Food - drug interactions that decrease drug effects

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pharmacology 4

Term	Definition
Additive effect	The effects produced by one or both of the drugs may be increased. ex aspirin + acetaminophen = more pain relief than either alone, but no unexpected boost 1+1=2
Antagonism	A drug-drug interaction or drug-food interaction that decreases or blocks the effect of another drug. 1 + 1 = 0 ⮚For example: Naloxone + opioid analgesics (e.g., morphine)
Drug-disease contraindication	Drug administration should be avoided because it may worsen the patient’s medical condition
Drug-drug interaction	Effect that occurs when two or more drugs are administered at the same time.
Drug-food interaction	Altered drug response that occurs when a drug is administered with certain foods.
Potentiation	The process where one drug, or a food, increases the effects of another drug yet does not produce any effect when administered alone. 1 + 0 = 2 for example: griseofulvin (antifungal) + fatty foods
Synergistic effects	Result when two drugs administered together produce effects that are greater than would be produced if either drug were administered alone.. ex warfarin + aspirin (increased bleeding) 1+1 =3
Therapeutic duplication	is the administration of multiple drugs that produce similar therapeutic effects and side effects, often from the same drug class
Bacteriostatic and bactericidal antiinfectives	⮚Interactions that decrease drug effects
“Azole” antifungals or fluoroquinolone antiinfectives and antacids	⮚Interactions that decrease drug effects
Penicillins and oral contraceptives	⮚Interactions that decrease drug effects
• Probenicid and penicillin • Alcohol and H2 receptor antagonists (e.g., cimetidine)	Interactions that increase drug effects
Atorvastatin and simavastatin—anticholesterol drugs—and grapefruit juice ⮚Dairy products and the antiinfective tetracycline ⮚Ferrous products (iron) and levothyroxine	Food - drug interactions that decrease drug effects

Created by: user-1991937

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