What are the 5 targets of antimicrobials?

1. Cell Wall production 2. Protein production (targert ribosome) 3. Disrupt cell membrane/lipid membrane 4. Inhibit metabolic pathway 5. Inhibit DNA or RNA production

What is bacteriostatic antibotics?

Stops bacterial growth/dividing, but doesn't necessarily kill the bacteria

How does the cell wall structure of a Gram negative bacteria affect antibiotic entry?

Outer lipid layer prevents entry of many antibiotics

What drug target will be most effective against Gram negative bacteria? Why?

Outer lipid layer- removes protection from the cell

What drug target will be most effective agaisnt Gram positive bacteria? Why?

Peptidoglycan- cells rely on thick layer of peptidoglycan for protection

How does a bacteria become antimicrobial resistantance?

Can be due to cell wall structure of from genes aquired from plasmids

What are the 5 mechanisms of antibiotic resistance?

1. Alter drug's target 2. In activate drug 3. Use efflux pump to reove drug from cell 4. Limit of block entry of drug 5. Stop using metabolic pathway or alter pathway being targeted

What does it mean when a bacteria is susceptible to an antiboitic?

that the antimicrobial is effictive agaisnt microbe

What does it mean when a bacteria is resistant to an antibiotic?

that the antimicrobial is NOT effective agaisnt microbe

What is the point of the Kirby-Bauer test?

used to determine effictiveness of different antimicrobials on a pathogen

How do you set up the Kirby-Bauer test?

1. Plate lawn of bacteria 2. add disks containg antibiotic that diffuse through agar 3. Creates a concentration gradient with highest amoun of antibiotic next to disk and less antibiotics as you move farther from disk

What is the Zone of Inhibition?

Clear area without mircobial growth around antibiotic

How would the inhibition zone of resistant bacteria look like?

It would have no inhibition or very small zone of inhibition

How would the inhibitiong zone of susceptible bacteria look like?

It would have a large zone of inhibition

What does MIC stand for?

Minimum Inhiibitory Concentration

what is the Minimum Inhibitory Concentration?

the lowest amount of antibiotic that will stop microbial growth

If your patient is allergic to the most effective antibiotic, what is another treatment option for this patient?

Give the antibiotic with intermeditate resistance at a higher dose?

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Lab Quiz 10

Question	Answer
What are the 5 targets of antimicrobials?	1. Cell Wall production 2. Protein production (targert ribosome) 3. Disrupt cell membrane/lipid membrane 4. Inhibit metabolic pathway 5. Inhibit DNA or RNA production
What is bacteriostatic antibotics?	Stops bacterial growth/dividing, but doesn't necessarily kill the bacteria
What are bactericidal antibiotics?	Kills the bacteria
How does the cell wall structure of a Gram negative bacteria affect antibiotic entry?	Outer lipid layer prevents entry of many antibiotics
What drug target will be most effective against Gram negative bacteria? Why?	Outer lipid layer- removes protection from the cell
What drug target will be most effective agaisnt Gram positive bacteria? Why?	Peptidoglycan- cells rely on thick layer of peptidoglycan for protection
How does a bacteria become antimicrobial resistantance?	Can be due to cell wall structure of from genes aquired from plasmids
What are the 5 mechanisms of antibiotic resistance?	1. Alter drug's target 2. In activate drug 3. Use efflux pump to reove drug from cell 4. Limit of block entry of drug 5. Stop using metabolic pathway or alter pathway being targeted
What does it mean when a bacteria is susceptible to an antiboitic?	that the antimicrobial is effictive agaisnt microbe
What does it mean when a bacteria is resistant to an antibiotic?	that the antimicrobial is NOT effective agaisnt microbe
What is the point of the Kirby-Bauer test?	used to determine effictiveness of different antimicrobials on a pathogen
How do you set up the Kirby-Bauer test?	1. Plate lawn of bacteria 2. add disks containg antibiotic that diffuse through agar 3. Creates a concentration gradient with highest amoun of antibiotic next to disk and less antibiotics as you move farther from disk
What is the Zone of Inhibition?	Clear area without mircobial growth around antibiotic
How would the inhibition zone of resistant bacteria look like?	It would have no inhibition or very small zone of inhibition
How would the inhibitiong zone of susceptible bacteria look like?	It would have a large zone of inhibition
What does MIC stand for?	Minimum Inhiibitory Concentration
what is the Minimum Inhibitory Concentration?	the lowest amount of antibiotic that will stop microbial growth
If your patient is allergic to the most effective antibiotic, what is another treatment option for this patient?	Give the antibiotic with intermeditate resistance at a higher dose?

Created by: user-1866205

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