Study of drugs and their action on the living organism-Looks at how the body responds to drugs that are administered

the study of how the body affects a drug: summarized by the acronym ADME: Absorption, Distribution, Metabolism, and Excretion.

Attraction that the receptor site has for the drug

Drug that binds to its receptor site and stimulates a cellular response. produce the maximum drug response.

Drug that binds to the receptor site and does not produce an action. prevents another drug or natural body chemical from binding and activating the receptor site. Example: Naloxone -have zero efficacy

Measure of a drug’s effectiveness.

Drug that has affinity and activity at the receptor site. The drug can turn “off” a receptor that is activated or turn “on” a receptor that is not currently active

describes how the drug produces its effect

Noncompetitive antagonist

Drug that binds to an alternative receptor site that prevents the agonist from binding to and producing its desired action

Drug that behaves like an agonist under some conditions and acts like an antagonist under different conditions- lower efficacy

Use of drugs in the treatment of disease and drug effects. It is the study of factors that influence patient response to drugs.

ratio of the effective dose to the lethal dose When the lethal dose of a drug is close to the effective dose, the drug is not very safe. Example: Digoxin

Drug–receptor theory

Drugs interact or bind with targeted cells in the body to produce pharmacologic action

The location of drug-cell binding

Competitive antagonists

compete with agonists for binding

steep dose-response curve

indicates that a small change in drug dose will produce a large change in the drug response.

flatter dose-response curve

small changes in drug dose produce little change

Drugs that have a high efficacy at a low dose

the phenomenon where a drug reaches its maximum possible effect, and increasing the dosage further does not increase its effectiveness

ADRs that produce harm to a developing fetus

Drugs and natural products that stimulate the growth of cancers

Person must continue to take the drug in order to prevent the onset of withdrawal symptoms.

Person must take increasing doses of the drug to produce the same effects as were previously produced by a lower dose.

a chemical substance that interferes with the normal metabolic processes within a cell/ often used as chemotherapy drugs because they prevent cancer cells from replicating

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pharmacology 3

Term	Definition
Pharmacodynamics	Study of drugs and their action on the living organism-Looks at how the body responds to drugs that are administered
pharmacokinetics	the study of how the body affects a drug: summarized by the acronym ADME: Absorption, Distribution, Metabolism, and Excretion.
Affinity	Attraction that the receptor site has for the drug
Agonist	Drug that binds to its receptor site and stimulates a cellular response. produce the maximum drug response.
Antagonist	Drug that binds to the receptor site and does not produce an action. prevents another drug or natural body chemical from binding and activating the receptor site. Example: Naloxone -have zero efficacy
Efficacy	Measure of a drug’s effectiveness.
Idiosyncratic reaction	unexpected drug interaction
Inverse agonist	Drug that has affinity and activity at the receptor site. The drug can turn “off” a receptor that is activated or turn “on” a receptor that is not currently active
Mechanism of action	describes how the drug produces its effect
Noncompetitive antagonist	Drug that binds to an alternative receptor site that prevents the agonist from binding to and producing its desired action
Partial agonist	Drug that behaves like an agonist under some conditions and acts like an antagonist under different conditions- lower efficacy
Pharmacotherapeutics	Use of drugs in the treatment of disease and drug effects. It is the study of factors that influence patient response to drugs.
Therapeutic index	ratio of the effective dose to the lethal dose When the lethal dose of a drug is close to the effective dose, the drug is not very safe. Example: Digoxin
Drug–receptor theory	Drugs interact or bind with targeted cells in the body to produce pharmacologic action
receptor site	The location of drug-cell binding
Competitive antagonists	compete with agonists for binding
steep dose-response curve	indicates that a small change in drug dose will produce a large change in the drug response.
flatter dose-response curve	small changes in drug dose produce little change
Potency	Drugs that have a high efficacy at a low dose
Ceiling Effect	the phenomenon where a drug reaches its maximum possible effect, and increasing the dosage further does not increase its effectiveness
Teratogenicity	ADRs that produce harm to a developing fetus
Carcinogenicity	Drugs and natural products that stimulate the growth of cancers
Dependence	Person must continue to take the drug in order to prevent the onset of withdrawal symptoms.
Tolerance	Person must take increasing doses of the drug to produce the same effects as were previously produced by a lower dose.
antimetabolite	a chemical substance that interferes with the normal metabolic processes within a cell/ often used as chemotherapy drugs because they prevent cancer cells from replicating

Created by: user-1991937

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