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Stack #4566385

QuestionAnswer
lactogenesis onset on milk production
developmental events required for lactogeneiss cell proliferation differentiation synthesis and secretion of milk components
key steps of lactogenesis parturition (calving) colostrum formation Transition to true milk Hormonal regulation
Parturition (lactogenesis) triggers hormonal changes that set the stage for the initiation of milk production
Colostrum formation after calving, mammary gland secretes colostrum and marks the first stage of lactogenesis
Transition to true milk colostrum becomes 'true milk' this stage involves a significant increase in milk production
Lactogenesis Stage I last 3-4 weeks of calving secretion of colostrum begins in alveoli tight junctions between epithelial cells are leaky high IgG1 transfer low lactose low water driven by prolactin and cortisol inhibited by progesterone
Lactogenesis Stage II 32-72hrs after birth triggered by rapid progesterone withdrawal increase in milk volume and lactose content tight junctions close transition from colostrum to true milk over 3-5 days prolactin and cortisol drive synthesis and lactose production
colostrum timing production begins in final weeks before birth essential for calves immediately for antibodies
colostrum composition high immunoglobulins high proteins high fat and fat soluble vitamins low lactose
colostrum low lactose prevents excessive hydration of calf GI tract nice on their tummies
colostrum function for calf provides antibodies passive immunity energy and thermoregulation gut maturation and immune support
progesterone in lactogenesis main inhibitor of lactogenesis supresses prolactin induced synthesis withdrawal of progesterone at birth = signals for stage 2 lactogenesis mediated by foetal cortisol, increased maternal oestrogen
prolactin surge at birth promotes tight junction closure, a-lactalbumin and casein transcription essential for lactation
cortisol prepares cell for prolactin response immobilises subtrates for milk synthesis promotes myometrial activity leading to birth
estrogen rises prepartum increased prolactin secretion promotes uterine oxytocin secretion
why is dry period needed dry period 6-8 weeks crucial for colostrum formation and mammary gland regeneration
tight junction stage I tight junction leaky
tight junction stage II tight junction closed blood-milk barrier keeps essential ions and minerals in yay
Created by: sakelleher29
 



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