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BIOL 1101 Exam Three

In-Class Notes, RAS Inh Cancer Therapy

QuestionAnswer
Which growth factor pathway is overactivated that affects proliferating signaling? tyrosine kinase-MAP signaling pathway
Why are growth factors important? in microorganism - cells can grow and divide when conditions are met in a multicellular organism - growth regulated to mammalian organs (need permission)
How do mammalian cells look like on a plate? have genetic changes, grow slowly or can't survive
How does fetal bovine serum help mammalian cells on a plate? provide growth factors to allow cells to grow properly
How were platelets determined as a growth factor? compared fibroblasts (required for PDGF to grow) between unclotted and clotted blood, activated platelets signaled to fibroblasts to grow and help
What receptor tyrosine kinase do PDGF, VEGF, and EGF bind to? PDGF - fibroblast, VEGF - blood vessel cell, EGF - epithelial cell
How do receptor tyrisone kinase react in response to ligand binding? form a dimer in response to growth factor and phosphorylate each other on specific tyrosine residues (cross phosphorylate by the activated kinase domain)
What is Ras? "small GTPase" that operates as a monomer, different class of G proteins from hterotrimerics
How is Ras activated? phosphorylated RTKs recruit proteins, Ras protein w/ GDP -> Active GTP Ras protein
What is the Ras Pathway? Ras-GTP -> MAPkinase cascade -> c-Myc allows genes to start on cell growth
Created by: goldengalleon
 



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