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Heart failure
| Question | Answer |
|---|---|
| Chronotropic drugs | affect the rate of the heart's contraction (heart rate and rhythm) by changing electrical impulses that regulate the hearts' rhythm |
| Inotropic drugs | increase the strength of the heart's contractions by altering calcium levels within the cardiac cells |
| Heart failure | Heart cannot pump enough blood to meet the tissue needs of the body |
| Left sided heart failure manifestations | Shortness of breath Moist cough Fluids backup previous to the left ventricle |
| Right sided heart failure manifestations | Peripheral edema venous congestion fluid backs up previous to the right ventricle of the heart (cor pulmonale) |
| Neurohormonal compensatory mechanisms in heart failure | - increased epinephrine and norepinephrine release - RAAS system activation - hypertrophy (remodeling of cardiac tissue) |
| Cardiotonics | digoxin (Lanoxin) |
| digoxin (Lanoxin) Cardiotonics MOA | positive inotropic activity=increased CO negative chronotropic effect= slowed HR allows blood to fill the heart chambers due to slowed HR |
| digoxin (Lanoxin) ADR | Visual disturbances- blurring or yellow halo Digitalis toxicity- GI symptoms Cardiac dysrhythmias |
| digoxin (Lanoxin) Contraindications | **Digitalis toxicity ventricular failure ventricular tachycardia cardiac tamponade restrictive cardiomyopathy AV block/heart block electrolyte imabalnce |
| digoxin (Lanoxin) Interactions | LOTS |
| digoxin (Lanoxin) Nursing interventions | Monitor for CNS effects (visual disturbances) Take apical pulse for 1 full minute before administration administer over 5 min via IV\digoxin immune Fab is antidote for digoxin toxicity |
| digoxin (Lanoxin) Client education | Report nausea, loss of appetite, or vomiting report palpitations monitor HR and report if outside parameters report signs of hypokalemia Risk of toxicity |
| Sympathomimetics | Increase cardiac output in severe HF but only used short-term via IV |
| dobutamine (Dobutrex) MOA | 1. dobutamine activates beta-adrenergic receptors causing a positive inotropic effect 2. increased forces of the heart increased CO 3. Increased CO leads to increased kidney perfusion |
| CNTD | 4. Increased kidney perfusion leads to increased sodium and urine excretion 5. Reduced fluid volume reduces workload of the heart |
| dobutamine (Dobutrex) ADR | Tachycardia Cardiac dysrhythmias anginal pain |
| dobutamine (Dobutrex) Interventions | Monitor ECG Vitals IV only, many incompatibilities, use dedicated line Decreased or discontinue drug for tachyrhythmias correct fluid volume deficit before administration |
| dobutamine (Dobutrex) Interactions | Beta blockers decrease effects |
| Vasopressor agents | used to increase blood pressure in acute hypotension due to cardiogenic, distributive, or septic shock |
| epinephrine (Adrenalin) MOA | non-selective adrenergic agonist that stimulates: - arterial vasoconstriction - positive chronotropic response - positive inotropic response |
| epinephrine (Adrenalin) Contraindications | no contraindications in life-threatening situations |
| epinephrine (Adrenalin) Interactions | interacts with 230 known drugs |
| epinephrine (Adrenalin) ADR | - hypertensive crisis - tissue necrosis and extravasation -tachycardia -seizures -cerebral hemorrhage |
| epinephrine (Adrenalin) Interventions | Central line hypovolemia corrected before infusion monitor apical pulse, BP, output, ecg to regulate dose Immediately report rise in BP monitor extravastion |
| vasopressin (Antidiuretic Hormone) use | for severe hypotension like shock - vasodilatory or hemorrhagic shock that is unresponsive to IV fluids |
| vasopressin (Antidiuretic Hormone) ADR | Increased BP Heart block decreased CO Angina sever peripheral vasoconstriction hemorrhagic shock FVO |
| vasopressin (Antidiuretic Hormone) contraindications | known hypersensitivity |
| vasopressin (Antidiuretic Hormone) Interactions | 295 drugs |