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7 - BB Learning

TermDefinition
Learning / Memory Learning - Change in Behaviour from Experience (acquiring knowledge) Knowledge AFFECTS Behaviour
Memory RETENTION Learned Information
Learning CHANGE IN BEHAVIOUR (EXPERIENCE)
Memory RETENTION OF LEARNED INFORMATION
MEMORY TYPES (2) Declarative Non Declarative
Declarative Memory Type Conscious YES Brain areas - Medial Temporal Lobe (Hippocampus) Example - Facts, Events, Names
Non Declarative Memory Type Conscious NO Brain areas - Cerebellum (movement), Striatum (Habits), Amygdala (emotions) Cerebellum, Striatum, Amygdala (emotions) Skills like riding a bike
LEARNING TYPES (2) Non Associative Associative
NON ASSOCIATIVE LEARNING TYPE Habituation, Sensitisation Response changes to repeated stimulus
ASSOCIATIVE Learning Type Classical and Instrumental Conditioning Associations between stimuli/events
Memory Systems Short term/Working Memory Long Term Memory
Short term/Working Memory 7 items, Easily disrupted, Prefrontal Cortex
Long Term Memory More Stable, May not need STM first Emotional/Spaced practice help
Neuroplasticity Brain changes with Experience
Learning Behaviour change with EXPERIENCE
Behaviour Change BRAIN
NeuroGENESIS NEW NEURONS (Dentate Gyrus - HIPPOCAMPUS)
HIPPOCAMPUS GENESIS - THINK OF HIPPOPOTAMUS EVOLVING
Dendritic branching/pruning More Input More Branches
Synaptic Plasticity Strengthening or Weakening of Synapses
Synaptic Plasticity involves LTP or LTD
LTP LONG TERM POTENTIATION SYNAPSES STRENGTHENS SYNAPSE more EPSPs Better Memory
LONG TERM DEPRESSION WEAKENS SYNAPSE "Unlearns" incorrect info
Key terms Hebb - Neurons that fire together wire together FIRE TOGETHER = WIRE TOGETHER Synaptic specifity, cooperativity, associativity: synapses active together are strengthened TOGETHER = STRENGTHENED NEURONS WIRE SYNAPSES STRENGTHEN
Molecular Mechanisms GLUtamate Receptors AMPA: Initial EPSP NMDA: Needs depolarisation (Mg2 block removed) allow Ca2+ entry -> triggers LTP
AMPA Initial EPSP
Depolarisation -> triggers LTP
High Frequency firing LTP (via CaMKII, PKC)
Low Frequency firing LTD (via phosphatases)
Neurogenesis Neural Stem Cells (Subependyma) SUBEPENDYMA Triggered by BDNF (Growth Factor) Reduced in depression Increased in antidepressants Antidepressents support Neurogenesis
Triggered by BDNF (Growth Factor) Exercise Enriched Environments Exercise and Enriched Environments
Key Research Models Aplysia (Sea Slugs) - Simple Nervous System, study LTP/LTD Morris water maze, Radial arm maze (Animals SPATIAL learning and memory) - SPATIAL and DECLERATIVE memory in RODENTS
Spatial memory Orientation in space Environment
HUMAN case studies Patient HM - Loss of Hippocampus -> Anterograde Amnesia (Can't form new declarative memories) but preserved Procedural Memory
Hippocampus DECLERATIVE MEMORIES
Anterograde Amnesia No Hippocampus No Declarative Memories Procedural Memory intact
Alzheimer's Disease Loss of Acetylcholine (ACh) Memory Loss Personality Changes Cognitive Decline
Alzheimer's Disease is treated With Cholinergic Drugs
Working Memory Involves Prefrontal Cortex Tested by Delayed Response Task Holds/Manipulates info short term (Eg mental arithmetic)
Working Memory Broken Down Prefrontal Cortex Delayed Response Task Holds info short term Mental arithmetic
WM How your memory works in day to day situations
Created by: brendonpizarro1
 

 



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