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Gout

QuestionAnswer
Gout A form of arthritis (inflammation of the joints) Uric acid crystals deposits in the joints
Antigout Agent colchicine Colcrys, Gloperba, Lodoco, Mitigaro
Antigout agent colchicine MOA Mediates the activation of interleukin 1B, an inflammatory mediator for acute gout
colchicine Deadly Interacts with statins, antifungals, and calcium channel blockers
colchicine Ineffective Not an analgesic GI symptoms
colchicine Weird Grapefruit juice interaction
Hyperuricemia Therapy-uricosurics Benemid Probalan (probenecid)
Benemid/Probalan (probenecid) MOA Increases amount of uric acid excreted in urine by inhibiting reabsorption in the convoluted tubule to reduce serum uric acid for chronic gout
Benemid/Probalan Deadly Anaphylaxis Renal colic
Benemid/Probalan Ineffective GI upset monitor CBC, urinary uric acid and serum uric acid polyuria drink fluids for kidney stone prevention
Benemid/Probablan weird Alopecia dermatitis puritis skin rash
Xanthene Oxidase inhibitor Zyloprim (allopurinol)
Zyloprim (allopurinol) Xanthene Oxidase inhibitor MOA Reduces production of uric acid in the body
Zyloprim (allopurinol) Deadly SJS DRESS- drug reaction with eosinophelia and systemic symptoms
Zyloprim (allopurinol) Ineffective LFT CBC Renal function test >2L output
Zyloprim (allopurinol) Weird 10 glasses of water daily 4-6 weeks for therapeutic effect
Created by: mdedobbe
 

 



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