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Osteoporosis

QuestionAnswer
Osteoporosis Bone weakness, loss of height, fractures, stooped posture, and join soreness with movement due to weakening of bones
Selective estrogen receptor modulator Evista (raloxifene)
Evista (raloxifene) Selective estrogen receptor modulator MOA Activates estrogen receptors in the bones to build and maintain strong bones
Evista Deadly Increased risk of thrombosis (thromboembolism) contraindicated with estrogen replacement meds
Evista ineffective Calcium and Vit D supplementation Add weight bearing exercises
Evista weird Hot flashes
Bisphosphonate Fosamax (alendronate)
Fosamax (alendronate) Bisphosphonate MOA Inhibits osteoclasts which strengthen bones by slowing down bone loss which also allows osteoblasts to work more effectively
Fosamax Deadly Hypocalcemia increased risk for aspiration
Fosamax Ineffective severe heartburn (esophagitis) NSAIDS increase GI side effects
Fosamax Werid Take first thing in the morning with a full glass of water
Monoclonal antibody against RANKL Prolia (denosumab)
Prolia (denosumab) Monoclonal antibody against RANKL MOA Inhibits osteoclast-mediated bone resorption by competing with RANKL (TNF) to bind
Prolia Deadly Severe hypocalcemia osteonecrosis of the jaw
Prolia Ineffective Supplement with Vit D and calcium Therapy will take years
Prolia weird Report s/s of infection therapy will take years subQ injection every 6 months
Anabolic agent (bone formation stimulating agent- parathyroid hormone) Forteo or Bonsity (teriparatide)
Forteo/Bonsity (teriparatide) Anabolic agent MOA Mimics effects of naturally occurring parathyroid hormone which regulates calcium, phosphate, and vitamin D metabolism in bones and kidneys
Forteo/Bonsity Deadly Hypercalcemia Toxicity
Forteo/Bonsity Ineffective Labs for serum calcium supplement calcium and vitamin D monitor for toxicity
Forteo/Bonsity Weird Self-injection daily
Calcitonin calcitonin-salmon, Miacalcin
Miacalcin calcitonin-salmon MOA Naturally occurring hormone in the thyroid that helps regulate calcium levels in the blood
Miacalcin Deadly Increased risk of malignancies antibody formation with paget's disease Hypocalcemia
Miacalcin Ineffective Vitamin D and calcium supplementation Serum calcium levels
Miacalcin Weird Alternate nostril daily Rotate injection sites
Calcium supplement Calcium citrate
Calcium citrate Deadly Hypercalcemia
Calcium citrate Ineffective Swelling Rapid weight gain 1.2 g/day
Calcium citrate Weird Swallow with full glass of water
Created by: mdedobbe
 

 



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