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Ceutics II Eaxm 1

QuestionAnswer
List acceptable reasons for a pharmacist to compound a product.
What grades of chemicals are preferred for drug compounding? What can be used instead if those are not available?
What are your general responsibilities as a compounder?
What are your responsibilities in terms of documentation, QA, and QC?
Give examples of quality assurance and examples of quality control. Is the completion of a compounding/manufacturing record QC or QA? Is visually inspecting the final product QC or QA?
List items present in Quality Assurance and observation techniques or tests that can be used in Quality Control.
List and discuss functions, incompatibilities, for packaging. Which ones protect products from light? Can protection from light be achieved through secondary packaging?
What is the difference between absorption and adsorption? Which process is involved in how materials from the packaging may enter your dosage form?
What is the difference between primary and secondary pharmaceutical packaging? Give examples of each type.
What are some basic considerations about beyond use dates for compounded formulas?
What are some of the advantages of using a solution? Readily available for absorption, Rapid drug action, Convenient administration, Dose uniformity, Easy manufacturing
What are various types of solvents for liquid preparations? Aqueous (Purified water, Sterile water for injection, Bacteriostatic water for injection), Non-aqueous alcohols (Ethanol, Glycerin, Propylene glycol, Polyethylene glycol), Non-aqueous oils (Olive oil, Sesame oil)
What is the minimum concentration of alcohol, glycerin, sucrose, isopropanol, and propylene glycol in a solution to inhibit the growth of microorganisms/self- preserving?
What are the maximum amounts of alcohol for oral formulas per age bracket?
What area some of the desired properties of sweetening agents?
What alternative solvents could be used for preservation of syrups and at what percentage? Ethanol (18%), Antimicrobial preservative Glycerin (50%), Propylene glycol (18%), Sucrose (85%)
The different types of solvents Aqueous (Purified water, Sterile water/Bacteriostatic water for injection), Non-aqueous Alcohols (Ethanol, Glycerin, Propylene glycol, Polyethylene), Non-aqueous Oils (Olive oil, Sesame oil)
Poisonous solvents that are never used in pharmaceutical formulations Methanol and Isopropanol
Recommended Ethanol limits for oral products Children below 6 years: 0.5%, Children between 6 and 12: 5%, Adults and children above 12 years: 10%
Makes good co-solvents (e.g. PEG 400, ethanol, propylene glycol, glycerin) Water-miscible
Long-chain triglycerides of vegetable origin (e.g. Peanut, corn, soybean, sesame, olive) Water-immiscible
Dielectric constant of Absolute Alcohol, Glycerin, Water Absolute Alcohol (25), Glycerin (46), Water (80)
Type of Solution: Syrup (Viscous aqueous solution containing a sweetener for oral administration), Aromatic water (Solution of aromatic material in aqueous solvent) Aqueous Solution
Type of Solution: Elixir (Sweetened hydro-alcoholic solution), Tinctures (Alcoholic or hydro-alcoholic solutions of plant extracts or chemical substances), Fluid Extract (Hydro-alcoholic solution containing 1g/mL extract of plant drug), Spirit/Essences (Solution of aromatic material in alcoholic solvent) Hydroalcoholic Solution
Type of Solution: Liniments (Alcoholic or oleaginous solution rubbed onto the skin), Collodions (Solution of pyroxylin (nitrocellulose from cotton) in alcohol/ether mixture) Nonaqueous Solution
Created by: tm15
 

 



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