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Ceutics II Eaxm 1
| Question | Answer |
|---|---|
| List acceptable reasons for a pharmacist to compound a product. | |
| What grades of chemicals are preferred for drug compounding? What can be used instead if those are not available? | |
| What are your general responsibilities as a compounder? | |
| What are your responsibilities in terms of documentation, QA, and QC? | |
| Give examples of quality assurance and examples of quality control. Is the completion of a compounding/manufacturing record QC or QA? Is visually inspecting the final product QC or QA? | |
| List items present in Quality Assurance and observation techniques or tests that can be used in Quality Control. | |
| List and discuss functions, incompatibilities, for packaging. Which ones protect products from light? Can protection from light be achieved through secondary packaging? | |
| What is the difference between absorption and adsorption? Which process is involved in how materials from the packaging may enter your dosage form? | |
| What is the difference between primary and secondary pharmaceutical packaging? Give examples of each type. | |
| What are some basic considerations about beyond use dates for compounded formulas? | |
| What are some of the advantages of using a solution? | Readily available for absorption, Rapid drug action, Convenient administration, Dose uniformity, Easy manufacturing |
| What are various types of solvents for liquid preparations? | Aqueous (Purified water, Sterile water for injection, Bacteriostatic water for injection), Non-aqueous alcohols (Ethanol, Glycerin, Propylene glycol, Polyethylene glycol), Non-aqueous oils (Olive oil, Sesame oil) |
| What is the minimum concentration of alcohol, glycerin, sucrose, isopropanol, and propylene glycol in a solution to inhibit the growth of microorganisms/self- preserving? | |
| What are the maximum amounts of alcohol for oral formulas per age bracket? | |
| What area some of the desired properties of sweetening agents? | |
| What alternative solvents could be used for preservation of syrups and at what percentage? | Ethanol (18%), Antimicrobial preservative Glycerin (50%), Propylene glycol (18%), Sucrose (85%) |
| The different types of solvents | Aqueous (Purified water, Sterile water/Bacteriostatic water for injection), Non-aqueous Alcohols (Ethanol, Glycerin, Propylene glycol, Polyethylene), Non-aqueous Oils (Olive oil, Sesame oil) |
| Poisonous solvents that are never used in pharmaceutical formulations | Methanol and Isopropanol |
| Recommended Ethanol limits for oral products | Children below 6 years: 0.5%, Children between 6 and 12: 5%, Adults and children above 12 years: 10% |
| Makes good co-solvents (e.g. PEG 400, ethanol, propylene glycol, glycerin) | Water-miscible |
| Long-chain triglycerides of vegetable origin (e.g. Peanut, corn, soybean, sesame, olive) | Water-immiscible |
| Dielectric constant of Absolute Alcohol, Glycerin, Water | Absolute Alcohol (25), Glycerin (46), Water (80) |
| Type of Solution: Syrup (Viscous aqueous solution containing a sweetener for oral administration), Aromatic water (Solution of aromatic material in aqueous solvent) | Aqueous Solution |
| Type of Solution: Elixir (Sweetened hydro-alcoholic solution), Tinctures (Alcoholic or hydro-alcoholic solutions of plant extracts or chemical substances), Fluid Extract (Hydro-alcoholic solution containing 1g/mL extract of plant drug), Spirit/Essences (Solution of aromatic material in alcoholic solvent) | Hydroalcoholic Solution |
| Type of Solution: Liniments (Alcoholic or oleaginous solution rubbed onto the skin), Collodions (Solution of pyroxylin (nitrocellulose from cotton) in alcohol/ether mixture) | Nonaqueous Solution |