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Neuro Pharm

Neuro drugs for exam 2 in Pharm.

QuestionAnswer
Seizure meds have what end goal? calm down the brain (stop excess neuron firing).
What are the 6 seizure meds? phenytoin, carbamazepine, oxcarbazapine, valopric acid, benzodiazepines, levetiracetam (keppra)
Phenytoin class? Hydantoins
Hydantoins do what action? block sodium
What makes phenytooin deadly? cardiac collapse when given too quickly
what makes phenytoin ineffective? alcohol/cns depressants
phenytoin 3 ADRs? gingival hyperplasia, SJS, drowsiness
phenytoin mnemonic? puffy gums and pulse drop given too quickly
carbamazepine class? anticonvulsants
carbamazepine action? block sodium
carbamazepine ineffective? grapefruit, HLA-B*1502 gene --> SJS, fluid retention
carbamazepine ADRs? bone marrow suppression, SJS, decrease blood cell production
carbamazepine mnemonic? carbs crush marrow
oxcarbazepine class? anticonvulsants
oxcarbazepine action block sodium
oxcarbazepine ineffective? use w/ phenytooin increase phenytoin levels, HLA-B*1502 gene --> SJS
oxcarbazepine ADRs? ostopenia, leukopenia, SJS, decrease bone marrow
carbamazepine and oxcarbazepine have what effect in common? decrease OHC effectiveness
oxcarbazepine mnemonic? oxy-carb decrease sodium
oxcarbazepine deadly? hyponatremia, SJS
carbamazepine deadly? bone marrow suppression, SJS
valopric acid class? anticonvulsant
valopric acid action? block sodium and calcium AND increase GABA
valopric acid deadly? hepatotoxicity, neural tube defecit (pregnant women)
valopric acid ineffective? topiramate increase ammonia levels (hyperammonemia)
valopic acid ADRs? GI manifestations, decreased platelets, and prolonged bleeding/bruising time. bone marrow suppression
valopric acid mnemonic? VAL=very angry liver
benzodiazepines class? anticonvulsant
benzodiazepine action? increase GABA to slow firing activity
benzodiazepine drugs end with? -pam, -lam
benzodiazepine deadly? respiratory depression, dependence and abuse
benzodiazepine ineffective? additive effect with other CNS depressants
benzodiazepine ADRs? amnesia, depression, sedation
benzodiazepine mnemonic? bezo=breathe slow
levetiracetam class? anticonvulsant
levetiracetam action? bind to SV2A protein to decrease neurotransmitter release
levetiracetam deadly? SJS (rare)
levetiracetam ineffective? additive effect with othe cns depressants
levetiracetam ADRs ? sleepiness, fatigue, mood swings
levetiracetam mnemonic? keep it simple w/ keppra
lidocaine class? local anesthesia
lidocaine action? block sodium in muscle to stop pain sensation
lidocaine deadly? respiratory arrest, cardiac arrest, seizures
lidocaine ineffective? beta blockers, cimetidine, quinidine increase lidocaine levels, phenytoin increase cardiac risk
lidocaine ADRS? hypotension (spinal), respiratory arrest, cns stimulant effect
lidocaine mnemonic? too much lido = lights out
multiple sclerosis drugs interferon beta 1a/interferon beta 1b
anesthesia drug lidocaine
seizure meds phenytoin, carbamazepine, oxcarbazepine, valopric acid, benzodiazepines, levetiracetam
interferon beta 1a/1b action? reduce inflammation and slow nerve damage
interferon beta 1a/1b deadly? hepatotoxicity, suicidal ideation, myelosupression
interferon beta 1a/1b ineffective? meds that suppress immune system
interferon beta 1a/1b ADRs? flu like symptoms, site redness/pain, myelosuppression
interferon beta 1a/1b mnemonic? better but bitter start, flu before you feel new
muscle spasm drugs? baclofen, dantrolene
muscle spasm overall goal? calm down skeletal muscles
baclofen class? CENTRAL acting skeletal muscle relaxant
baclofen action? increase GABA in spinal cord and sent signals out
baclofen deadly? withdrawal --> seizures or psychosis
baclofen ineffective? alcohol/cns depressants increase sedation, serotonin syndrome with antidepressants (MAOI-B)
baclofen ADRs? constipation, urinary retention, drowsiness/dizziness
baclofen mnemonic? Bac is BACK
dantrolene class? PERIPHERAL Acting Skeletal Muscle Relaxant
dantrolene action? block calcium in muscle to decrease spasm
dantrolene ineffective? alcohol/cns depressants increase sedation, calcium channel blocker increase cardiac dysrhythmias
dantrolene deadly? hepatotoxicity (estrogen use in women >35yrs), dysrhythmias
what else can dantrolene treat? malignant hyperthermia
dantrolene ADRs? muscle weakness, diarrhea, dizziness/drowsiness
dantrolene mnemonic? dan burns liver and goes straight to source
Created by: KWard3
 

 



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