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Rheumatoid arthritis

QuestionAnswer
Rheumatoid arthritis Chronic autoimmune disorder that causes inflammation of joints, eventual bone erosion and joint deformity
Conventional Synthetic Non-biologic DMARD Methotrexate
Methotrexate: conventional synthetic non-biologic DMARD MOA Slows joint degeneration and progression of RA by immune suppression
Methotrexate deadly Cytotoxicity/immunosuppression hepatic toxicity bone marrow suppression
Methotrexate ineffective Methotrexate + tetracylcine= methotrexate toxicity folic acid must be administered with to prevent hepatic and GI toxicity LFTs
Methotrexate weird Contraindicated with PUD and ulcerative collitis notify provider with signs of infection
Biologic DMARD TNF agonist Enbrel etanercept
Enbrel (etanercept) Biologic DMARD TNF agonist MOA Suppress immune response and inflammation by inhibiting TNF-alpha an inflammatory cytokine
Enbrel (etanercept) Deadly Avoid live immunizations (immunosuppression) TB screening
Enbrel (etanercept) ineffective/weird Weekly subQ injections
Targeted synthetic DMARD Xeljanz (tofacitinib)
Xeljanz (tofacitinib) Targeted synthetic DMARD MOA Suppress immune system by inhibiting JAK 1 and JAK 3 which are inflammatory cytokines
Xeljanz Deadly blood clots in lungs, v + a in legs and arms serious infections tears in stomach or intestines
Xeljanz Ineffective TB screening avoid live immunizations because of immunosuppression
Xeljanz Weird grapefruit juice interaction
Rheumatoid arthritis symptoms low-grade fever weakness fatigue loss of appetite joint pain, swelling, redness, and tenderness
Created by: mdedobbe
 

 



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