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BDK: GI 2
25-26 LIST
| GENERIC | BRAND | CATEGORY | INDICATION | SIDE EFFECTS | US BOXED WARNING | NOTES |
|---|---|---|---|---|---|---|
| Famotidine | Pepcid/Zantac 360 | Histamine (H2) antagonist | GERD, erosive esophagitis, SUP | headache, constipation, diarrhea, mental status changes | ||
| Metoclopramide | Reglan | Dopamine (D2) antagonist | Gastroparesis, GERD, nausea, vomiting | drowsiness, dystonia, akathisia, EPS, QTc prolongation, diarrhea, hyperprolactinemia | may cause tardive dyskinesia, do not use >12 weeks | CI with GI obstruction, perforation, or hemorrhage |
| Ondansetron | Zofran | Selective serotonin (5-HT3) antagonist | Nausea, vomiting | headache, fatigue, constipation, QTc prolongation | ||
| Promethazine | Phenergan | Histamine (H1) antagonist | Motion sickness, nausea, vomiting | drowsiness, dry mouth, blurred vision, QTc prolongation, EPS | potential for fatal respiratory depression in patients < 2 years old; injection can cause peripheral extravasation (preferred parenteral route is IM) | |
| Meclizine | Bonine | Histamine (H1) antagonist | Motion sickness, Vertigo | drowsiness, dry mouth, blurry vision | ||
| Diphenoxylate and Atropine | Lomotil | Antidiarrheal | Diarrhea | nausea, confusion, drowsiness, dizziness, xerostomia, tachycardia, urinary retention | do not use in diarrhea associated with enterotoxin-producing bacteria or in children <6 years of age | |
| Dexlansoprazole | Dexilant | Proton pump inhibitor (PPI) | GERD, PUD, erosive esophagitis, SUP | headaches, abdominal pain, nausea, diarrhea, bone fracture, vitamin B12 deficiency, hypomagnesemia, increased risk of Clostridioides difficile associated diarrhea (CDAD) | ||
| Esomeprazole | Nexium | Proton pump inhibitor (PPI) | GERD, PUD, erosive esophagitis, SUP | headaches, abdominal pain, nausea, diarrhea, bone fracture, vitamin B12 deficiency, hypomagnesemia, increased risk of Clostridioides difficile associated diarrhea (CDAD) | ||
| Lansoprazole | Prevacid | Proton pump inhibitor (PPI) | GERD, PUD, erosive esophagitis, SUP | headaches, abdominal pain, nausea, diarrhea, bone fracture, vitamin B12 deficiency, hypomagnesemia, increased risk of Clostridioides difficile associated diarrhea (CDAD) | ||
| Omeprazole | Prilosec | Proton pump inhibitor (PPI) | GERD, PUD, erosive esophagitis, SUP | headaches, abdominal pain, nausea, diarrhea, bone fracture, vitamin B12 deficiency, hypomagnesemia, increased risk of Clostridioides difficile associated diarrhea (CDAD) | ||
| Pantoprazole | Protonix | Proton pump inhibitor (PPI) | GERD, PUD, erosive esophagitis, SUP | headaches, abdominal pain, nausea, diarrhea, bone fracture, vitamin B12 deficiency, hypomagnesemia, increased risk of Clostridioides difficile associated diarrhea (CDAD) | ||
| Sucralfate | Carafate | Gastrointestinal protectant | duodenal ulcers | constipation, bezoar formation | take on an empty stomach; many drug interactions due to reducing absorption of other drugs |