Save
Upgrade to remove ads
Busy. Please wait.
Log in with Clever
or
show password
Forgot Password?
Don't have an account?  Sign up 
Sign up using Clever
or
Username is available taken
show password


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account. Your email address is only used to allow you to reset your password. See our Privacy Policy and Terms of Service.

Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.
focusNode
Didn't know it?
click below
 
Knew it?
click below
Don't Know
Remaining cards (0)
Know
0:00
edit
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

ch 13 toxicology

QuestionAnswer
Which drug is listed as causing nonimmune-mediated (nonallergic) idiosyncratic hepatotoxicity? Isoniazid, an antituberculosis drug with nonimmune-mediated effects.
Which of the following is an example of an immune-mediated idiosyncratic hepatotoxicity drug? Halothane, an anesthetic linked to allergic reactions in the liver.
What is a key factor in the pathogenesis of idiosyncratic liver injury? Enhanced individual susceptibility with failure to adapt to drug reactions.
How does ethanol exposure contribute to mitochondrial damage? It shifts the bioactivation/detoxification balance, accumulating acetaldehyde.
Nucleoside analog reverse transcriptase inhibitors can cause what type of mitochondrial damage? They often cause miscoding or early termination of polypeptides.
What happens to mitochondrial DNA (mtDNA) due to its reduced repair capacity? It is more vulnerable to miscoding (mutation) than nuclear DNA
What is one observation indicating the role of sinusoidal immune cells in liver injury? Pretreatments that activate/inactivate Kupffer cells modulate damage.
What additional concept does the danger hypothesis add to the hapten hypothesis? Damaged cells release cytokines that generate costimulatory signals.
According to the hapten hypothesis, what presents reactive metabolites to th cells APCs (antigen-presenting cells) with MHC II molecules effectively.
What is the consequence if liver injury is too severe and cell proliferation is inhibited? The dose-responsive regeneration capacity is exceeded quickly.
Carbon tetrachloride exposure primarily leads to what cellular disturbance? Disturbances of Ca ++ homeostasis and necrotic cell death.
Created by: aceofspades08
 

 



Voices

Use these flashcards to help memorize information. Look at the large card and try to recall what is on the other side. Then click the card to flip it. If you knew the answer, click the green Know box. Otherwise, click the red Don't know box.

When you've placed seven or more cards in the Don't know box, click "retry" to try those cards again.

If you've accidentally put the card in the wrong box, just click on the card to take it out of the box.

You can also use your keyboard to move the cards as follows:

If you are logged in to your account, this website will remember which cards you know and don't know so that they are in the same box the next time you log in.

When you need a break, try one of the other activities listed below the flashcards like Matching, Snowman, or Hungry Bug. Although it may feel like you're playing a game, your brain is still making more connections with the information to help you out.

To see how well you know the information, try the Quiz or Test activity.

Pass complete!
"Know" box contains:
Time elapsed:
Retries:
restart all cards