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Muscle spasm

QuestionAnswer
Muscle spasm MS, cerebral palsy, spinal cord injury, spasms
Therapeutic pathway peripheral and CNS neurotransmitters and receptors
Centrally acting antispasmodics MOA Enhance inhibitory effects of GABA on receptors in spinal cord which suppresses hyperactive reflexes
Balcofen Centrally acting antispasmodic
Balcofen DEADLY Serotonin syndrome MAOI x2 weeks Don't drive Do not stop infusion pump abruptly
Balcofen INEFFECTIVE Sedation Dry mouth Urinary retention Constipation Take with food or milk
Balcofen WEIRD Taper if on meds >4 weeks Dry, dry, dizzy: lozenges, fluids + effect with other antichollinergics
Peripherally acting antispasmodics treats: Muscle spasm from stroke Spinal cord injury MS Cerebral palsy Malignant hyperthermia from anesthesia
Peripherally acting antispasmodic MOA Acts directly on skeletal muscle tissue by inhibiting release of calcium which inhibits normal muscle contraction
Dantrolene Peripherally acting antispasmodic
Dantrolene DEADLY Liver toxicity Severe cardiac dysrhythmias in clients who take calcium channel blockers
Dantrolene INEFFECTIVE Prolonged diarrhea Take 1-2 days pre-op
Dantrolene WEIRD Given via IV if malignant hyperthermia is found during surgery + effect with other CNS depressants
Created by: mdedobbe
 

 



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