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Multiple sclerosis
| Question | Answer |
|---|---|
| Multiple sclerosis | CNS disease in which auto-reactive T-cells attack the myelin sheath of nerves. Disrupts the flow and communication between brain and body |
| Therapeutic pathway | Pain receptors inflammation and immune modulators |
| MOA | Immunomodulators inhibit the movement of leukocytes across the blood-brain barrier which protects the myelin sheath from damage |
| Beta 1A interferons | immunomodulators treating MS |
| Beta 1A DEADLY | Liver toxicity myelosuppression immune suppression |
| Beta 1A INEFFECTIVE | Flu-like symptoms |
| Beta 1A WEIRD | relapsing remitting ONLY supportive care rotate injection sites |
| Beta 1B interferons | Immunomodulators inhibit the movement of leukocytes across the blood-brain barrier which protects the myelin sheath from damage |
| Beta 1B DEADLY | Liver toxicity (LFTS) myelosuppression immune suppresion |
| Beta 1B INEFFECTIVE | Flu-like symptoms |
| Beta 1B WEIRD | Relapsing-remitting AND continuous MS (b for Both) supportive care rotate injection sites! |