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PHO 3

Pharmacologic CategoryGeneric NameBrand NameCommon IndicationsSE
Antimetabolite (Folic Acid Antagonist) Methotrexate (PO, IV, IT) Trexall RA, Crohn's Disease, Psoriasis, Various hematologic and solid tumors SE: Mouth sores, N/V/D, low blood counts, liver/lung toxicity. BBW: Fetal harm, marrow/GI toxicity, NSAID risks. Folic acid reduces toxicity.
Antineoplastic agent, platinum-based compound Cisplatin (IV, IT, IP) Kemoplat Advanced bladder, ovarian, and testicular cancer; various cancer SE: Marrow suppression, N/V, kidney, nerve & hearing toxicity. BBW: Severe myelosuppression, N/V (needs antiemetics), renal toxicity, neuropathy.
Antineoplastic agent, anthracycline Doxorubicin (IV) Adriamycin Adjuvant therapy for breast cancer, various cancers SE: Heart damage, hair loss, N/V, marrow suppression. BBW: Cardiomyopathy, secondary cancers, tissue necrosis. Note: Red body fluids.
Antineoplastic agent, monoclonal antibody Prembrolizumab (IV) Keytruda Various cancers SE: Edema, rash, itching, endocrine changes, N/V/D, ↑LFTs/Cr, dyspnea, hematuria, anemia, fatigue, muscle/joint pain.
Aromatase inhibitor Anastrozole (PO) Arimidex Hormone receptor-positive breast cancer SE: Fatigue, rash, flushing, hot flashes, joint pain, N/V, HTN, edema, osteoporosis. Risks: High cholesterol, CAD, fetal harm. CI: Pregnancy.
Selective estrogen receptor modulator (SERM) Tamoxifen (PO) Soltamox Hormone receptor-positive breast cancer SE: Hot flashes, night sweats, vaginal bleeding, bone loss. BBW: Uterine CA, clots. Note: Use contraception; avoid with warfarin or DVT/PE.
Created by: jcresend
 

 



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