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Pharm Ch. 8

Pharm Ch. 8 Self Test

QuestionAnswer
What is the mechanism of action of nystatin (Mycostatin, Nilstat)? Increasing membrane permeability
Candida albicans is a frequent inhabitant of the oral cavity, and frequently causes fungal infections. The first part is true, the second part is false.
The most frequent adverse drug effect of the imidazoles involves which body system? GI system
Which is the most serious adverse drug effect of ketoconazole (Nizoral)? Hepatotoxicity
When is ketoconazole indicated? In the treatment and manage risk for mucocutaneous and oropharyngeal candidiasis.
What is used to treat oropharyngeal and esophageal candidiasis and serious candidal infections, to treat vaginal candidiasis, and prophylactically in immunocompromised patients or for treatment of candidal infections that do not respond to other agents? Fluconazole (Diflucan)
What is the mechanism of action for the antiviral agent acyclovir (Zovirax)? Nucleic acid analogues that inhibit DNA synthesis
What are indications for the use of acyclovir? Herpes simplex 1 and 2, Varicella-zoster virus, Epstein-Barr virus, Cytomegalovirus
What is most correct concerning acyclovir's actions? Produces a shortened duration of the viral shedding
Medications used in the management of oral herpes simplex include what? Zidovudine (AZT, Retrovir)
Nystatin, miconazole, clotrimazole, and ketoconazole are given to treat what condition? Candida albicans
What is NOT a category of medication used to treat HIV/AIDS? Imidazoles - these treat fungal infections, not HIV
What categories of medications are used to treat chronic hepatitis B? Interferons, nucleoside/nucleotide analogues
What is the mechanism of action of the imidazoles in treatment for fungal infections? INcreased cell membrane permeability
What is the most common adverse reaction associated with the antifungal agent ketoconazole? GI distress, nausea, and vomiting
The primary difference between the action of protease inhibitors and nonnucleoside reverse transcriptase inhibitors and the nucleoside reverse transcriptase inhibitors is that the protease inhibitors...? Interfere with action of an HIV-infected cell
Patients with HIV using highly active antiretroviral therapy (HAART) will take a combination of which drugs? Nucleoside, a nonnucleoside reverse transcriptase inhibitor, and a protease inhibitor
Which agents are indicated for the treatment of recurrent genital herpes? Famciclovir, valacyclovir
Medications for treatment and prevention of influenza does NOT include what agent? Interferon
Do antiviral agents work with a similar mechanism of action as antibacterial drugs? No
WHat has FDA approval to treat hepatitis B and C? Interferon alpha
Created by: jridder25
 

 



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