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BDK: PAIN/HEMA/ONC 3

25-26 LIST

GENERICBRANDCATEGORYINDICATIONSIDE EFFECTSBOXED WARNINGNOTES
Methotrexate Trexall Antimetabolite (Folic Acid Antagonist) Rheumatoid arthritis, Crohn’s Disease, psoriasis, various hematologic and solid tumors stomatitis, diarrhea, nausea, vomiting, thrombocytopenia, leukopenia, increased hepatic transaminases, pulmonary fibrosis (rare) serious toxic reactions, may cause fetal death and/or congenital abnormalities (avoid in pregnancy); severe (sometimes fatal) bone marrow suppression, aplastic anemia, and toxicity have been reported with concomitant administration of methotrexate and NSAIDs; may cause hepatotoxicity; methotrexate-induced lung disease, including acute or chronic interstitial pneumonitis may occur; severe (sometimes fatal) gastrointestinal toxicity has been reported with concomitant administration with NSAIDs Folic acid supplementation may be taken during use to reduce hematologic, gastrointestinal, and hepatic side effects
Cisplatin Kemoplat Antineoplastic Agent, Platinum-Based Compound Advanced bladder, ovarian, and testicular cancer; various cancers bone marrow suppression, nausea, vomiting, nephrotoxicity, neurotoxicity, ototoxicity may cause severe myelosuppression, nausea and vomiting, renal toxicity, and dose-related neuropathy
Doxorubicin Adriamycin Antineoplastic Agent, Anthracycline Adjuvant therapy for breast cancer, various cancers cardiomyopathy, alopecia, nausea, vomiting, bone marrow suppression may cause cardiomyopathy, myelosuppression, secondary malignancies; extravasation can result in severe local tissue injury and necrosis may cause red discoloration of urine, tears, sweat, and saliva
Pembrolizumab Keytruda Antineoplastic Agent, Monoclonal Antibody Various Cancers peripheral edema, pruritus, skin rash, endocrine and metabolic abnormalities, constipation, diarrhea, nausea, vomiting, hematuria, anemia, increased liver enzymes, fatigue, musculoskeletal pain, increased serum creatinine, dyspnea
Anastrozole Arimidex Aromatase Inhibitor Hormone Receptor-Positive Breast Cancer fatigue, rash, flushing, hot flashes, arthralgia, nausea, vomiting, hypertension, peripheral edema, osteoporosis cardiovascular side effects (i.e., hypercholesterolemia, CAD); fetal toxicity (CI in pregnancy)
Tamoxifen Soltamox Selective Estrogen Receptor Modulator (SERM) Hormone Receptor-Positive Breast Cancer hot flashes/night sweats, vaginal bleeding/discharge, decreased bone density (in premenopausal females) increased risk for uterine or endometrial cancer and thromboembolic events contraception should be used in premenopausal females due to teratogenicity of the drug; do not use with warfarin or history DVT/PE
Created by: aleeciagene
 

 



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