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BDK: PAIN/HEMA/ONC 2
25-26 LIST
| GENERIC | BRAND | CATEGORY | INDICATION | SIDE EFFECTS | BOXED WARNING/NOTES | CLASS |
|---|---|---|---|---|---|---|
| Hydrocodone and Acetaminophen | Lortab/Vicodin/Norco | Opioid and Nonopioid Analgesic Combination | Pain | dizziness, drowsiness, nausea, vomiting, constipation, pruritus, respiratory depression (dose-related) | use with CYP3A4 inhibitors (or stopping CYP3A4 inducers) can increase oxycodone concentrations; hepatotoxicity | CS-II |
| Oxycodone and Acetaminophen | Percocet/Endocet | Opioid and Nonopioid Analgesic Combination | Pain | dizziness, drowsiness, nausea, vomiting, constipation, pruritus, respiratory depression (dose-related) | use with CYP3A4 inhibitors (or stopping CYP3A4 inducers) can increase oxycodone concentrations; hepatotoxicity | CS-II |
| Codeine and Acetaminophen | Tylenol with Codeine #3/ Tylenol with Codeine #4 | Opioid and Nonopioid Analgesic Combination | Pain | dizziness, drowsiness, nausea, vomiting, constipation, pruritus, respiratory depression (dose-related) | concomitant use or discontinuation of CYP3A4 inducers, 3A4 inhibitors, or 2D6 inhibitors requires careful consideration; respiratory depression and death in children after tonsillectomy or adenoidectomy who are ultra-rapid metabolizers of codeine; hepatotoxicity | CS-III |
| Naloxone | Narcan/Zimhi | Opioid Antagonist | Opioid Overdose | opioid withdrawal syndrome in opioid-dependent populations, pain | Nasal Spray: OTC | |
| Buprenorphine and Naloxone (SL) | Suboxone | Partial Opioid Agonist and Opioid Antagonist | Opioid Use Disorder | opioid withdrawal syndrome in opioid-dependent populations, constipation, headache, diaphoresis | potentially life-threatening respiratory depression (when combined with other CNS and respiratory depressants); addition of naloxone to buprenorphine reduces the possibility of parenteral misuse by producing opioid withdrawal symptoms when injected | CS-III |
| Ferrous Sulfate | FeroSul/SlowFe | Iron Supplement | Iron Deficiency Anemia | nausea, stomach upset, constipation (dose-related), dark and tarry stools | accidental overdose of iron is leading cause of fatal poisoning in children under 6 years old | OTC |
| Cyanocobalamin (B12) | Water-soluble vitamin | Vitamin B12 deficiency (macrocytic anemia) | OTC | |||
| Folic Acid | Water-soluble vitamin | Folic acid deficiency (macrocytic anemia), prevention of neural tube defects in pregnancy | OTC |