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BDK: PAIN/HEMA/ONC 1
25-26 LIST
| GENERIC | BRAND | CATEGORY | INDICATION | SIDE EFFECTS | BOXED WARNINGS | CLASS |
|---|---|---|---|---|---|---|
| Fentanyl (Transdermal) | Duragesic | Opioid Analgesic | Pain | dizziness, drowsiness, nausea, vomiting, constipation, pruritus, respiratory depression (dose-related) | potential for medication errors when converting between dosage forms; use with CYP3A4 inhibitors (or stopping CYP3A4 inducers) can increase fentanyl concentrations; avoid exposing transdermal patch to external heat | CS-II |
| Fentanyl (IV) | Sublimaze | Opioid Analgesic | Pain | dizziness, drowsiness, nausea, vomiting, constipation, pruritus, respiratory depression (dose-related) | potential for medication errors when converting between dosage forms; use with CYP3A4 inhibitors (or stopping CYP3A4 inducers) can increase fentanyl concentrations; | CS-II |
| Hydromorphone | Dilaudid | Opioid Analgesic | Pain | dizziness, drowsiness, nausea, vomiting, constipation, pruritus, respiratory depression (dose-related) | risk of medication errors with high-potency hydromorphone, use in opioid-tolerant patients only | CS-II |
| Morphine Extended-Release | MS Contin/Kadian | Opioid Analgesic | Pain | dizziness, drowsiness, nausea, vomiting, constipation, pruritus, respiratory depression (dose-related) | congestion with alcohol may result in potentially fatal overdose of morphine | CS-II |
| Morphine Immediate Release | IV: Duramorph/Infumorph | Opioid Analgesic | Pain | dizziness, drowsiness, nausea, vomiting, constipation, pruritus, respiratory depression (dose-related) | CS-II | |
| Oxycodone | Oxycontin/Roxicodone | Opioid Analgesic | Pain | dizziness, drowsiness, nausea, vomiting, constipation, pruritus, respiratory depression (dose-related) | use with CYP3A4 inhibitors (or stopping CYP3A4 inducers) can increase oxycodone concentrations | CS-II |
| Methadone | Dolophine | Opioid Analgesic | Opioid Use Disorder, Severe Chronic Pain | dizziness, drowsiness, nausea, vomiting, constipation, respiratory depression (dose-related), QTc prolongation | QTc interval prolongation and serious arrhythmia (Torsades de Pointes) have occurred during treatment; concomitant use with CYP3A4, 2B6, 2C19, or 2D6 (or stopping the same inducers) can increase methadone concentrations | CS-II |
| Acetaminophen (PO/PR) | Tylenol | Non-Opioid Analgesic, Antipyretic | Pain, Fever | nausea, vomiting, increased hepatic transaminases | total daily dose from all sources should not exceed maximum daily limit; hepatotoxicity | OTC |
| Acetaminophen (IV) | Ofirmev | Non-Opioid Analgesic, Antipyretic | Pain, Fever | nausea, vomiting, increased hepatic transaminases | total daily dose from all sources should not exceed maximum daily limit; hepatotoxicity | Rx |
| Tramadol | Ultram/ER | Partial Opioid Agonist; Central Analgesic | Pain | dizziness, drowsiness, nausea, vomiting, constipation, respiratory depression (dose-related) | lowers seizure threshold | CS-IV |