Save
Upgrade to remove ads
Busy. Please wait.
Log in with Clever
or
show password
Forgot Password?
Don't have an account?  Sign up 
Sign up using Clever
or
Username is available taken
show password


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account. Your email address is only used to allow you to reset your password. See our Privacy Policy and Terms of Service.

Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.
focusNode
Didn't know it?
click below
 
Knew it?
click below
Don't Know
Remaining cards (0)
Know
0:00
edit
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

ID EXAM 5 DRUGS

DRUGMOAMORADRNOTES
Acyclovir (zovirax) competitive inhibitions of viral DNA pol by acyclovir triphosphate converted to phosphate form through thymine kinase stop sythesis of viral DNA disturbs 3'-5' phosphodiester bond reduction of tymidine kinase IV is dose limited by nephrotoxicity, crystalluria and neurotoxicity converted to monophosphate form through thymidine kinase
Valacyclovir (valtrex) same as acyclovir oral prodrug, better absorbtion from ester groups reduction of tymidine kinase nausea, vomit
Famiciclovir (prodrug of penciclovir) Famiciclovir is oral, due to two acetyl ester groups Penciclovir is topical for herpes labialis
Ganciclovir, valganciclovir MOA: similar to acyclovir but uses UL97 gene encoded phosphotransferase istead of thymine kinase IN CMV Valganciclovir is the prodrug of genciclovir Mutations in viral phosphotransferaase BOXED WARNING: hematologic toxicity, fetal toxicity, impairmetn of fertility, mutagenic and carcinogenic used for HCMV retinitis and prevention of HCMV after transplant
Cidofovir (only nucleotide) Does not require specific thymidine kinase BOXED WARNING: nephrotoxicty, neutropenia (prevent with saline) use against acyclovir resistant HSV and ganciclovir resistant HCMV
Foscarnate Inhibition of viral DNA pol electrolyte imbalances, neurotoxicity, phlebitis, N/V CMV renitis in AIDS pts acyclovir resistant HSV and VZV
Letermovir (prevymis) inhibits acivity of terminase complex pUL56 non-nucleoside so no cross resistance CYP3A4 cyclosporine increases BA
Created by: beezy41
 

 



Voices

Use these flashcards to help memorize information. Look at the large card and try to recall what is on the other side. Then click the card to flip it. If you knew the answer, click the green Know box. Otherwise, click the red Don't know box.

When you've placed seven or more cards in the Don't know box, click "retry" to try those cards again.

If you've accidentally put the card in the wrong box, just click on the card to take it out of the box.

You can also use your keyboard to move the cards as follows:

If you are logged in to your account, this website will remember which cards you know and don't know so that they are in the same box the next time you log in.

When you need a break, try one of the other activities listed below the flashcards like Matching, Snowman, or Hungry Bug. Although it may feel like you're playing a game, your brain is still making more connections with the information to help you out.

To see how well you know the information, try the Quiz or Test activity.

Pass complete!
"Know" box contains:
Time elapsed:
Retries:
restart all cards