The desired effect is excessive

Dose-related reaction that is not part of the desired therapeutic outcome

An aspect of the patient's condition that makes the use of a certain drug or therapy an unwise or dangerous decision

Idiosyncratic Reaction

Genetically related abnormal drug response

Immunologic response to a drug resulting in a reaction such as a rash or anaphylaxis

Interference with natural defense mechanisms

When a drug reduces the body's ability to fight of infections

Abnormality in fetal development caused by exposure to certain substances, such as drugs, chemicals or infections during pregnancy.

Type 1 Hypersensitivity

Immediate hypersensitivity reactions. IgE antibodies. Produces edema, and the inflammatory response. Bronchioles, resulting in anaphylactic shock. Respiratory, results in rhinitis and asthma. Skin results in urticaria.

Type 2 Hypersensitivity

IgG or IgM antibodies. Antibody complex is fixed to a circulating blood cell causing lysis. Results in anemia.

Type 3 Hypersensitivity

Aggregations of antigens and antibodies, where antibodies out number antigens forming clumps. Manifesting as serum sickness, urticarial, arthritis, lymphadenopathy, and fever.

Type 4 Hypersensitivity

Delayed hypersensitivity. Sensitized T-lymphocytes and macrophages. Manifests as allergic contact dermatitis, poison oak, poison ivy, reaction to jewelry, topical benzocaine, etc.

General discomfort or pain in the upper abdomen. Symptoms include: bloating, nausea and indigestion.

Broad term that refers to any inflammation of the mouth and lips, including the cheeks, gums, lips, tongue and roof or floor of the mouth.

A specific type of stomatitis involving painful inflammation and ulcerations of the mucous membranes in the mouth, most commonly as a side effect of cancer treatments like chemotherapy and radiation therapy.

Stevens-Johnson Syndrome

A rare but serious disorder of the skin and mucous membranes. Typically triggered by a severe reaction to medications or less commonly, infections.

Is an acute, immune-mediated skin condition characterized by the sudden appearance of distinctive target-like bullseye lesions, often triggered by infections or medications.

Premature death of cells or tissues in the body due to factors like injury, infection, or lack of blood flow.

Commonly known as hives, is a skin condition that is characterized by raised, itchy welts or bumps.

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Chapter 3 -Adverse R

Adverse Reactions

Term	Definition
Therapeutic Effect	Clinically desirable actions
Adverse Effects	Undesirable reactions
Toxic Reactions	The desired effect is excessive
Side Effect	Dose-related reaction that is not part of the desired therapeutic outcome
Contraindiction	An aspect of the patient's condition that makes the use of a certain drug or therapy an unwise or dangerous decision
Idiosyncratic Reaction	Genetically related abnormal drug response
Drug Allergy	Immunologic response to a drug resulting in a reaction such as a rash or anaphylaxis
Interference with natural defense mechanisms	When a drug reduces the body's ability to fight of infections
Teratogenic Effect	Abnormality in fetal development caused by exposure to certain substances, such as drugs, chemicals or infections during pregnancy.
Type 1 Hypersensitivity	Immediate hypersensitivity reactions. IgE antibodies. Produces edema, and the inflammatory response. Bronchioles, resulting in anaphylactic shock. Respiratory, results in rhinitis and asthma. Skin results in urticaria.
Type 2 Hypersensitivity	IgG or IgM antibodies. Antibody complex is fixed to a circulating blood cell causing lysis. Results in anemia.
Type 3 Hypersensitivity	Aggregations of antigens and antibodies, where antibodies out number antigens forming clumps. Manifesting as serum sickness, urticarial, arthritis, lymphadenopathy, and fever.
Type 4 Hypersensitivity	Delayed hypersensitivity. Sensitized T-lymphocytes and macrophages. Manifests as allergic contact dermatitis, poison oak, poison ivy, reaction to jewelry, topical benzocaine, etc.
Dyspepsia	General discomfort or pain in the upper abdomen. Symptoms include: bloating, nausea and indigestion.
Stomatitis	Broad term that refers to any inflammation of the mouth and lips, including the cheeks, gums, lips, tongue and roof or floor of the mouth.
Oral Mucositis	A specific type of stomatitis involving painful inflammation and ulcerations of the mucous membranes in the mouth, most commonly as a side effect of cancer treatments like chemotherapy and radiation therapy.
Stevens-Johnson Syndrome	A rare but serious disorder of the skin and mucous membranes. Typically triggered by a severe reaction to medications or less commonly, infections.
Erythema Multiforme	Is an acute, immune-mediated skin condition characterized by the sudden appearance of distinctive target-like bullseye lesions, often triggered by infections or medications.
Necrosis	Premature death of cells or tissues in the body due to factors like injury, infection, or lack of blood flow.
Urticaria	Commonly known as hives, is a skin condition that is characterized by raised, itchy welts or bumps.

Created by: HBrown22

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