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Adverse Reactions
| Question | Answer |
|---|---|
| Therapeutic effects | clinically desirable actions |
| Toxic reaction | the desired effect is excessive |
| Adverse effects | undesirable reactions |
| Side effect | dose-related reaction that is not part of the desired therapeutic outcome |
| Contraindication | an aspect of a patients condition that makes the use of a certain drug or therapy an unwise or dangerous decision |
| Idiosyncratic reaction | genetically related abnormal drug response |
| Drug Allergy | immunologic response to a drug resulting in a reaction such as a rash or anaphylaxis |
| Interference with natural defense mechanisms | when a drug reduces the body's ability to fight infections |
| Teratogenic Effect | abnormality in fetal development caused by exposure to certain substances, such as drugs, chemicals, or infections during pregnancy |
| Type I hypersensitivity | Immediate hypersensitivity reactions. IgE antibodies: produces vasodilation, edema and the inflammatory response. bronchioles, resulting in anaphylactic shock. Respiratory, results in rhinitis and asthma. Skin results in urticaira |
| Type II hypersensitivity | IgG or IgM antibodies. Antibody complex is fixed to a circulating blood cell causing lysis. Results in anemia |
| Type III hypersensitivity: | aggregations of antigens and antibodies, where antibodies out number antigens forming clumps: manifested as serum sickness, urticarial, arthritis, lymphadenopathy and fever. |
| Type IV hypersensitivity | Delayed hypersensitivity. Sensitized T-lymphocytes and macrophages. Manifests as allergic contact dermatitis, poison oak, poison ivy, reaction to jewelry, topical benzocaine, etc.. |
| Dyspepsia | general discomfort or pain in the upper abdomen: symptoms bloating, nausea, and indigestion |
| Stomatitis | a broad term that refers to any inflammation of the mouth and lips, including the cheeks, gums, tongue, lips, and roof or floor of the mouth |
| Oral Mucositis | A specific type of stomatitis involving painful inflammation and ulcerations of the mucous membranes in the mouth, most commonly as a side effect of cancer treatments like chemotherapy and radiation therapy |
| Stevens-Johnson Syndrome | is a rare but serious disorder of the skin and mucous membranes, typically triggered by a severe reaction to medications or, less commonly, infections |
| Erythema multiforme | is an acute, immune-mediated skin condition characterized by the sudden appearance of distinctive target-like (bullseye) lesions, often triggered by infections or medications |
| Necrosis | premature death of cells or tissues in the body due to factors like injury, infection, or lack of blood flow |
| Urticaria | commonly known as hives, is a skin condition characterized by raised, itchy welts or bumps |
| Exaggerated Effect on Target Tissue | Is considered an extension of the therapeutic effect caused by the overreaction of a sensitive patient or by the use of a dose that it too large |
| Effect on Nontarget Tissues | Caused by the nontherapeutic action of the drug |
| Effect on Fetal Development(Teratogenic Effect) | The adverse relationship between drugs and its affects on the developing fetus. |
| Local Effect | Characterized by local tissue irritation |
| Hypersensitivity (Allergic Reaction) | Occurs when the immune system of an individual responds to the drug administered or applied. This reaction is neither dose dependent nor predictable. |
| Idiosyncrasy | is a reaction that is neither a drug's side effect nor an allergic reaction |
| Interference with natural defense mechanisms | when a drug's effect on the body's defense mechanism and results in an adverse reaction |
| Teratogenic | refers to something that can cause birth defects or harm to a developing baby during pregnancy |
| Pregnancy Trimesters | pregnancy is divided into 3 trimesters, each lasting about 3 months |
| Risk to Benefit Ratio | is a way to compare the potential risks and benefits of a decision or treatment |
| Contraindicated | something, like a medication or treatment, should not be used because it could be harmful in certain situations. |
| Lactation | is the process of producing milk in the breasts after childbirth, allowing the mother to feed her baby |
| Fetal Alcohol Syndrome | a condition in babies cause by a mother drinking alcohol during pregnancy, it can lead to physical and mental disabilities, including growth problems, facial abnormalities and learning difficulties |
| Neonate | is a newborn baby, specifically within the first 28 days of life |
| Syndactyly | condition where two or more fingers or toes are fused together, either partially or completely at birth |
| Oligodactyly | condition where a person is born with fewer than the usual number of fingers or toes |
| Spina bifida | a birth defect where the spinal cord doesn't develop properly=, leaving a gap in the spine. This can lead to physical and neurological problems |
| Jaundice | is a condition where the skin and eyes turn yellow due to a buildup of bilirubin, a substance produced when the body breaks down red blood cells. Often a sign of liver problems |
| 1st Trimester | organs in the fetus are forming No x-rays and elective dental treatment should be avoided |
| 2nd Trimester | Excellent time for the patient to receive both oral health instructions and dental prophylaxis treatment, if needed. Check carefully for the patient's periodontal health |
| 3rd Trimester | Closest to delivery Difficult for patient to lie prone for any length of time. Patient may need to to sitting or with the right hip elevation. This is the stage that premature labor is most likely to begin. |