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Pharm 2.5

QuestionAnswer
When does peptic ulcer disease occur? Occurs when acid in the digestive tract eats away at the inner surface of the stomach or small intestine
Proton Pump Inhibitors include Prazole, prilosec, and protonix.
What do proton pump inhibitors treat? Ulcers, GERD, esophagitis, H. Pylor, Zollinger Ellison Syndrome
Proton pump inhibitor MOA Reduces acid secretion in the stomach by binding irreversibly to the enzyme H+ K+, TPase
Adverse effects of PPIs NVD, abdominal pain, headache
Long term effects of PPIs Osteoporosis, C diff, PNA, hypomagnesemia. Can decrease effectiveness of clopidogrel, and increases bleeding risk of warfarin
Metoclopramide Uses, administration, contraindication, SE Antiemetic, used for N/V, gastroparesis, and GERD. administered 4x a day on an empty stomach. Contraindications - Epilepsy, GI obstruction, history of tardive dyskinesia. SE: Tardive dyskinesia, sedation, fatigue, restlessness.
Famotidine (Pepcid) Uses, administration, contraindication, SE H2 receptor antagonist, suppresses volume and acidity of parietal cell secretions. Uses: Indiestion, short term GERD, Duodenal ulcers 6-8wks, gastric ulcers 12 wks, and zollinger ellison syndrome.
SE of pepcid Diarrhea, headache, dizziness, rash, tiredness.
Sucralfate Uses, administration, contraindication, SE Used to treat PUD. Makes protective barrier in the stomach that promotes ulcer healing. Can stick to an ulcer for up to 6 hours. 2 hour separation from phenytoin, warfarin, cipro, and digoxin. 4x a day
 

 



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