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Ceutics E4
How much you understand is a first order rxn
| Question | Answer |
|---|---|
| dehydration | A reaction whereby a drug losses water |
| solvolysis | Splitting of a drug molecule via a solvent molecule |
| hydrolysis | Splitting of a drug molecule via water |
| photolysis | The splitting of a drug molecule via light |
| oxidation | A reaction whereby atoms in a drug molecule gain oxygen or lose electrons. |
| reduction | A reaction whereby atoms in a drug molecule lose oxygen or gain electrons. |
| Racemization | A reaction whereby a drug converts from one enantiomeric form to another (thalidomide) |
| Enantiomers | Chiral molecules that are mirror images of one another (hands) |
| degradation | Breakdown of a drug to form a different molecule |
| zero order reaction | Reaction rate is independent of concentration of reactants |
| first order reaction | Reaction rate is dependent on the concentration of one of the reactants |
| second order reaction | Reaction rate is dependent on concentrations of two reactants |
| Pseudo zero order reaction | In reality, rxn rate is dependent on the [drug]. However, because [drug] in rxn is practically constant, it appears that the rxn rate is independent of drug concentration. Typically observed in hydrolysis of drugs in liquid susp dosage forms |
| Pseudo first order reaction | rxn rate is dependent on the [ ] of more than one reactant. However, the rxn rate appears to be depdt. on the [ ]of only one of the reactants because the [ ] of other reactants is practically constant. Typically observed in hydrolysis of drugs in solns |
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