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PHO 1
| Parmacologic Category | Generic Name | Brand Name | Classification | Common Indication | EK |
|---|---|---|---|---|---|
| Opiod Analgesic | fentyl (Transdermal, IV) | Transdermal: Duragesic IV: Sublimaze | CS-II | Pain | US Boxed Warning (only for fentanyl): potential for medication errors when converting between dosage forms; use with CYP3A4 inhibitors (or stopping CYP3A4 inducers) can increase fentanyl concentrations; avoid exposing transdermal patch to external heat |
| Opiod Analgesic | hydromophone (PO, IV) | Dilaudid | CS-II | Pain | US Boxed Warning (only for hydromorphone): risk of medication errors with high-potency hydromorphone, use in opioid-tolerant patients only |
| Opiod Analgesic | morphine (Extended Release) (PO) | MS Contin, Kadian | CS-II | Pain | US Boxed Warning (only for morphine, extended release): coingestion with alcohol may result in potentially fatal overdose of morphine |
| Opiod Analgesic | morphine (Immediate Release)(PO, IV, IM, PR) | IV: Duramorph, Infumorph | CS-II | Pain | KSE: dizziness, drowsiness, N/V, constipation, pruritus, resp. depression. BW: addiction/abuse → OD/death; fatal resp. depression; accidental ingestion; neonatal withdrawal; abrupt D/C → withdrawal; CNS depressants → coma/death. |
| Opiod Analgesic | oxycodone (PO) | OxyContin, Roxicodone | CS-II | Pain | US Boxed Warning (only for oxycodone): use with CYP3A4 inhibitors (or stopping CYP3A4 inducers) can increase oxycodone concentrations |
| Opiod Analgesic | methadone (PO, IV) | Dolophine | CS-II | Opiod use disorder, severe chronic pain | KSE: dizziness, drowsiness, N/V, constipation, resp. depression, QTc prolongation. BW: QTc prolongation/TdP; CYP3A4/2B6/2C19/2D6 interactions or stopping inducers may ↑ methadone levels. |
| Analgesic (non-opioid) Antipyretic | acetaminophen (PO, PR, IV) | PO/PR: Tylenol IV: Ofirmev | PO, PR: OTC | Pain, Fever | Key Side Effects: nausea, vomiting, increased hepatic transaminases US Boxed Warnings: total daily dose from all sources should not exceed maximum daily limit; hepatotoxicity |
| Central Analgesic; partial opiod agonist | tramadol (PO) | Ultram, Ultram ER | CS-IV | Pain | KSE: dizziness, drowsiness, N/V, constipation, resp. depression. BW: addiction/abuse→OD/death; fatal resp. depression; accidental OD; neonatal withdrawal; CNS depressants→coma/death; CYP3A4/2D6 interactions; child death. ON: ↓ seizure threshold. |