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PHO 2
PAIN, HEMATOLOGY, AND ONCOLOGY 2
| brand | generic | category | class | indication | key side effects | box warnings | other notes |
|---|---|---|---|---|---|---|---|
| Lortab, Vicodin, Norco | hydrocodone and acetaminophen (PO) | Opioid and nonopioid analgesic combination | CS -II | Pain | Key Side Effects: dizziness, drowsiness, nausea, vomiting, constipation, pruritus, respiratory depression (dose-related) | US Boxed Warnings: use with CYP3A4 inhibitors (or stopping CYP3A4 inducers) can increase oxycodone concentrations; hepatotoxicity | |
| Percocet, Endocet | oxycodone and acetaminophen (PO) | Opioid and nonopioid analgesic combination | CS -II | Pain | Key Side Effects: dizziness, drowsiness, nausea, vomiting, constipation, pruritus, respiratory depression (dose-related) | US Boxed Warnings: use with CYP3A4 inhibitors (or stopping CYP3A4 inducers) can increase oxycodone concentrations; hepatotoxicity | |
| Tylenol with Codeine #3, Tylenol with Codeine #4 | codeine and acetaminophen (PO) | Opioid and nonopioid analgesic combination | CS - III | Pain | Key Side Effects: dizziness, drowsiness, nausea, vomiting, constipation, pruritus, respiratory depression (dose-related) | ||
| Narcan Nasal Spray, Zimhi | naloxone (IV, IM, SQ, intranasal) | Opioid antagonist | Narcan Nasal Spray: OTC | Opioid overdose | Key Side Effects: opioid withdrawal syndrome in opioid-dependent populations, pain | ||
| Suboxone | buprenorphine and naloxone (SL) | Partial opioid agonist and opioid antagonist | CS - III | Opioid use disorder | Key Side Effects: opioid withdrawal syndrome in opioid-dependent populations, constipation, headache, diaphoresis | potentially life-threatening respiratory depression (when combined with other CNS and respiratory depressants); addition of naloxone to buprenorphine reduces the possibility of parenteral misuse by producing opioid withdrawal symptoms when injected | |
| FeroSul, SlowFe | ferrous sulfate (PO) | Iron supplement | OTC | Iron deficiency anemia | Key Side Effects: nausea, stomach upset, constipation (dose-related), dark and tarry stools | US Boxed Warning: accidental overdose of iron is leading cause of fatal poisoning in children under 6 years old | |
| cyanocobalamin (vitamin B12 ) (PO, IM, SL, intranasal | Water-soluble vitamin | PO, SL: OTC | Vitamin B12 deficiency (manifests as macrocytic anemia) | no major side effects | |||
| folic acid (PO) | Water-soluble vitamin | OTC | Folic acid deficiency (manifests as macrocytic anemia), prevention of neural tube defects in pregnancy | no major side effects |