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PHO 1

PAIN, HEMATOLOGY, AND ONCOLOGY 1

brandgenericcategoryclass indicationkey side effectsbox warningother notes
Transdermal: Duragesic, IV: Sublimaze fentanyl (transdermal, IV) Opioid analgesic CS - II Pain Key Side Effects: dizziness, drowsiness, nausea, vomiting, constipation, pruritus, respiratory depression (dose-related) US Boxed Warning (only for fentanyl): potential for medication errors when converting between dosage forms; use with CYP3A4 inhibitors (or stopping CYP3A4 inducers) can increase fentanyl concentrations; avoid exposing transdermal patch to external heat
Dilaudid hydromorphone (PO, IV) Opioid analgesic CS - II Pain Key Side Effects: dizziness, drowsiness, nausea, vomiting, constipation, pruritus, respiratory depression (dose-related) US Boxed Warning (only for hydromorphone): risk of medication errors with high-potency hydromorphone, use in opioid-tolerant patients only
MS Contin, Kadian morphine (extended release)(PO) Opioid analgesic CS - II Pain Key Side Effects: dizziness, drowsiness, nausea, vomiting, constipation, pruritus, respiratory depression (dose-related) US Boxed Warning (only for morphine, extended release): coingestion with alcohol may result in potentially fatal overdose of morphine
IV: Duramorph, Infumorph morphine (immediate release) (PO, IV, IM, PR) Opioid analgesic CS - II Pain Key Side Effects: dizziness, drowsiness, nausea, vomiting, constipation, pruritus, respiratory depression (dose-related)
OxyContin, Roxicodone oxycodone (PO) Opioid analgesic CS - II Pain Key Side Effects: dizziness, drowsiness, nausea, vomiting, constipation, pruritus, respiratory depression (dose-related) US Boxed Warning (only for oxycodone): use with CYP3A4 inhibitors (or stopping CYP3A4 inducers) can increase oxycodone concentrations
Dolophine methadone (PO, IV) Opioid analgesic CS - II Opioid use disorder, severe chronic pain Key Side Effects: dizziness, drowsiness, nausea, vomiting, constipation, respiratory depression (dose-related), QTc prolongation QTc interval prolongation and serious arrhythmia (Torsades de Pointes) have occurred during treatment; concomitant use with CYP3A4, 2B6, 2C19, or 2D6 (or stopping the same inducers) can increase methadone concentrations
PO/PR: Tylenol, IV: Ofirmev acetaminophen (PO, PR, IV) Analgesic (non-opioid), antipyretic PO, PR: OTC Pain, fever Key Side Effects: nausea, vomiting, increased hepatic transaminases US Boxed Warnings: total daily dose from all sources should not exceed maximum daily limit; hepatotoxicity
Ultram, Ultram ER tramadol (PO) Central analgesic; partial opioid agonist CS -IV Pain Key Side Effects: dizziness, drowsiness, nausea, vomiting, constipation, respiratory depression (dose-related) Other Notes: lowers seizure threshold PR: per rectum
Created by: user-1986059
 

 



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