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endocrine 2
| brand | generic | category | indication | key side effects | box warnings | other notes |
|---|---|---|---|---|---|---|
| Yasmin 28, Yaz | drospirenone and ethinyl estradiol (PO) | Contraceptive | Contraception, acne | Key Side Effects: nausea, changes in menstrual flow, breast tenderness, thromboembolic disorders, headache, weight gain | US Boxed Warnings: increased risk of cardiovascular events in women >35 years old who smoke | Other Notes: CI in hepatic dysfunction, thromboembolic disorders, breast cancer, migraines with aura, and cardiovascular disease |
| Lutera, Levora, Seasonique | levonorgestrel and ethinyl estradiol (PO) | Contraceptive | Contraception, acne | Key Side Effects: nausea, changes in menstrual flow, breast tenderness, thromboembolic disorders, headache, weight gain | US Boxed Warnings: increased risk of cardiovascular events in women >35 years old who smoke | Other Notes: CI in hepatic dysfunction, thromboembolic disorders, breast cancer, migraines with aura, and cardiovascular disease |
| Junel, Loestrin, Microgestin | norethindrone and ethinyl estradiol (PO) | Contraceptive | Contraception, acne | Key Side Effects: nausea, changes in menstrual flow, breast tenderness, thromboembolic disorders, headache, weight gain | US Boxed Warnings: increased risk of cardiovascular events in women >35 years old who smoke | Other Notes: CI in hepatic dysfunction, thromboembolic disorders, breast cancer, migraines with aura, and cardiovascular disease |
| Lo Loestrin Fe, Microgestin Fe | norethindrone, ethinyl estradiol, and ferrous fumarate (PO) | Contraceptive | Contraception, acne | Key Side Effects: nausea, changes in menstrual flow, breast tenderness, thromboembolic disorders, headache, weight gain | US Boxed Warnings: increased risk of cardiovascular events in women >35 years old who smoke | Other Notes: CI in hepatic dysfunction, thromboembolic disorders, breast cancer, migraines with aura, and cardiovascular disease |
| Tri-Sprintec, Sprintec | norgestimate and ethinyl estradiol (PO) | Contraceptive | Contraception, acne | Key Side Effects: nausea, changes in menstrual flow, breast tenderness, thromboembolic disorders, headache, weight gain | US Boxed Warnings: increased risk of cardiovascular events in women >35 years old who smoke | Other Notes: CI in hepatic dysfunction, thromboembolic disorders, breast cancer, migraines with aura, and cardiovascular disease |
| Crysell-28, Low-Ogestrel | norgestrel and ethinyl estradiol (PO) | Contraceptive | Contraception, acne | Key Side Effects: nausea, changes in menstrual flow, breast tenderness, thromboembolic disorders, headache, weight gain | US Boxed Warnings: increased risk of cardiovascular events in women >35 years old who smoke | Other Notes: CI in hepatic dysfunction, thromboembolic disorders, breast cancer, migraines with aura, and cardiovascular disease |
| Premarin | estrogens, conjugated (equine) (PO, topical) | Estrogen derivative | Vasomotor symptoms associated with menopause, vaginal atrophy associated with menopause | Key Side Effects: irritation at application site (transdermal patch only), edema, abdominal pain, breast tenderness, weight gain, thromboembolic disorders (myocardial infarction, stroke, VTE) | US Boxed Warnings: higher risk of breast cancer; shouldn't be used for dementia prevention; higher risk of endometrial cancer if not used concomitantly with progestin in women with a uterus; should not be used for prevention of cardiovascular disease | Other Notes: CI in hepatic dysfunction, thromboembolic disorders, cardiovascular disease, breast cancer, and estrogen-dependent tumor |
| Transdermal: Climera, Vivelle Dot PO: Estrace | estradiol (transdermal, PO) | Estrogen derivative | Vasomotor symptoms associated with menopause, vaginal atrophy associated with menopause | Key Side Effects: irritation at application site (transdermal patch only), edema, abdominal pain, breast tenderness, weight gain, thromboembolic disorders (myocardial infarction, stroke, VTE) | US Boxed Warnings: higher risk of breast cancer; shouldn't be used for dementia prevention; higher risk of endometrial cancer if not used concomitantly with progestin in women with a uterus; should not be used for prevention of cardiovascular disease | Other Notes: CI in hepatic dysfunction, thromboembolic disorders, cardiovascular disease, breast cancer, and estrogen-dependent tumor |
| Provera | medroxyprogesterone (PO) | Progestin | Abnormal uterine bleeding, secondary amenorrhea | Key Side Effects: acne, abnormal menstrual bleeding, headache, amenorrhea, weight gain | US Boxed Warnings: increased risk of breast cancer; should not be used for dementia prevention; should not be used for prevention of cardiovascular disease | Other Notes: CI in thromboembolic disorders, cardiovascular disease, estrogen or progesterone-dependent tumors, undiagnosed abnormal genital bleeding, hepatic impairment |