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Chapter 2 Definition

TermDefinition
Low Dose-Effect Curve Measuring the response to the dose of the drug
Potency The amount of drug required to produce an effect
Efficacy Related to the maximal effect of a drug regardless of dose or Is the maximum intensity of effect or response that can be produced by a drug
Therapeutic Action/Effect The intended or desired result
Therapeutic Range Range between the dose causing the minimum effect and the dose causing the minimum adverse effect
Therapeutic Index (TI) Number that determines the safety of a drug. (Greater TI means safer the drug)
Renal Kidney
Hepatic Liver
Biotransformation Is the body's way of changing a drug so that it can be more easily excreted by the kidneys
Tolerance The need for an increasing larger dose of the drug to obtain the same effects as the original
Duration The length of the drugs effect
Half-Life Is the amount of time that passes for its concentration to fall to half of its original blood level
Median Effect Dose (ED50) Is the dose required to produce a desired clinical effect in 50% of the test subjects. A low effective dose is preferred because it means less drugs are needed to achieve the desired therapeutic effect.
Lethal Dose (LD50) Is the amount of a substance that causes death in 50% of a test population. A low LD means the substance is more toxic.
Created by: HBrown22
 

 



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