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BDK: CNS 3
25-26 LIST
| GENERIC | BRAND | CATEGORY | INDICATIONS | SIDE EFFECTS | BOXED WARNING | NOTES |
|---|---|---|---|---|---|---|
| Lithium | Lithobid | Antimanic Agent | Bipolar disorder | tremor, acne, hypothyroidism, weight gain, polyuria, polydipsia, GI upset | ability to promptly monitor levels is necessary | narrow therapeutic index drug (toxicity may occur at concentrations close to therapeutic range; therapeutic drug monitoring is recommended); avoid in pregnancy |
| Sumatriptan | Imitrex | Antimigraine | Migraine | fatigue, somnolence, dizziness, chest tightness, paresthesias | --- | CI in ischemic heart disease, history of stroke or TIA, peripheral vascular disease, and uncontrolled hypertension |
| Rizatriptan | Maxalt | Antimigraine | Migraine | fatigue, somnolence, dizziness, chest tightness, paresthesias | --- | CI in ischemic heart disease, history of stroke or TIA, peripheral vascular disease, and uncontrolled hypertension |
| Halopreidol | Haldol | First-generation antipsychotic | Schizophrenia | sedation, EPS, parkinsonism, xerostomia, orthostatic hypotension, weight gain, QTc prolongation | elderly patients with dementia-related psychosis treated with antipsychotic drugs at increased risk of death | --- |
| Clozapine | Clozaril | Second-generation antipsychotic | Treatment-resistant schizophrenia | sedation, constipation, orthostatic hypotension, sialorrhea, hyperglycemia, weight gain, neutropenia | may cause severe neutropenia; may cause orthostatic hypotension, bradycardia, and syncope; may cause seizures; may cause fatal myocarditis and cardiomyopathy; elderly patients with dementia-related psychosis treated with antipsychotic drugs at increased risk of death | --- |
| Aripiprazole | Abilify/Aristada | Second-generation antipsychotic | Schizophrenia, bipolar disorder, MDD (adjunct to antidepressants) | akathisia, restlessness, sedation, EPS, constipation, orthostatic hypotension, weight gain | antidepressants increase the risk of suicidal thinking and behavior in children, adolescents and young adults; elderly patients with dementia-related psychosis treated with antipsychotic drugs at increased risk of death | --- |
| Quetiapine | Seroquel/XR | Second-generation antipsychotic | Schizophrenia, bipolar disorder, MDD (adjunct to antidepressants) | sedation, EPS, constipation, orthostatic hypotension, weight gain | antidepressants increase the risk of suicidal thinking and behavior in children, adolescents and young adults; elderly patients with dementia-related psychosis treated with antipsychotic drugs at increased risk of death | --- |
| Lurasidone | Latuda | Second-generation antipsychotic | Schizophrenia, bipolar disorder, MDD (adjunct to antidepressants) | sedation, EPS, constipation, orthostatic hypotension, weight gain | antidepressants increase the risk of suicidal thinking and behavior in children, adolescents and young adults; elderly patients with dementia-related psychosis treated with antipsychotic drugs at increased risk of death | CI with strong 3A4 inhibitors and inducers |
| Olanzapine | Zyprexa | Second-generation antipsychotic | Schizophrenia, bipolar disorder, MDD (adjunct to antidepressants) | sedation, EPS, xerostomia, constipation, orthostatic hypotension, weight gain, hyperglycemia | elderly patients with dementia-related psychosis treated with antipsychotic drugs at increased risk of death | --- |
| Risperidone | Risperdal (Consta) | Second-generation antipsychotic | Schizophrenia | sedation, EPS, xerostomia, constipation, orthostatic hypotension, weight gain, hyperglycemia | elderly patients with dementia-related psychosis treated with antipsychotic drugs at increased risk of death | --- |