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BioChem C7:E1
Chapter 7 Exam 1
| Question | Answer |
|---|---|
| proteins transport functions | myoglobin (o2 thouhout muscles), hemoglobin (o2 transport in blood) structural |
| actin (protein structural function) | forms microfilaments in cells |
| tubuin (protein structural function) | dimers constiture microtubles |
| keratin (protein structural function) | filaments constitute the bulk of animal hair |
| collagen (protein structural function) | is a major protein in connective tissue |
| protein motor function | myosin interacts with actin filaments to facilitate muscular movement, kinesin moves along microtubules to support a variety of cellular functions |
| protein other functions | catalysis, immunity, regulation of gene expression |
| myogobin | hemeprotein, monomer, primarily in muscle, o2 binds to the heme group of in a hyperbolic manner, 3D |
| hemoglobin | tetra (a2:b2), erythrocytes, 02 binds to the heme group ina sigmoidal manner, quat |
| myoglobin structure | tertiary |
| hemoglobin structure | quad |
| T or F, the similarities in structure and sequence between myoglobin and hemoglobin indicate a common evolutionary orin | T |
| T or F , proteins can act in the following way, transport, structural, motor function, immunity | T |
| T or F, myoglobin transports o2 through the blood | F |
| o2 transport is necessary for | life |
| hemoglobin mutation can lead to | disease |
| Heme is a ______ group found in myoglobin and hemoglobin | prosthetic group |
| prosthetic group definition | organic molecule bound to protein that aids protein funtion |
| heme is a _______ that chelates iron for oxygen transport | porphyrin |
| myoglobin transports o2 vis the ____ in heme | Fe |
| what amino acid residue plays a key role in anchoring both 02 and iron | His |
| myoglobin binds to o2 in a hyperbolic trend | true |
| Mb and Hb are similar in their secondary and tertiary structures | true |
| Homologous protiens | evolving from a common ancestor gene through genetic mutation |
| invariant residues | identical in homologous proteins, essential for structure or function of the proteins, cannot be replaced by other residues |
| conservative residues | when an amino acid can be replaced by another similar amino acid |
| variable residues | not involved in the structure or function of the protein, can be substituted by other dissimilar amino acid ( |
| o2 can bind cooperatively to hemoglobin as the protein shifts from the deoxy to the oxy conformation | modulatioin of hemoglobin function in vivo (bohr) |
| hemogloin binds in a _____ curve | sigmoidal, indicative of cooperatively |
| cooperativity | binding of 02 to one subunit induces easier binding to other subunits |
| bohr effect | the reduction of hemoglobins oxygen bindin affinity when the pH decreases |
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