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Cholinergic PCOL E2

Cholingergic PCOL E2 Drug List

DrugsMOASOASide EffectsExtra Information
Acetylcholine Methacholine Carbachol Bethanechol Non-selective Muscarinic Agonist (M1,M2,M3) Central and Periphery DUMBBELSS
Pilocarpine Cevimeline Non-selective Muscarinic Agonist (M1,M2,M3) Central and Periphery DUMBBELSS Treatment of dry mouth / glaucoma
Atropine Non-selective Muscarinic Antagonist (M1,M2,M3) Central and Periphery Anti-DUMBBELSS Treatment of Organophosphate poisoning (severe DUMBBELSS) Treatment of muscarinic agonist overdose
Scopalamine Non-selective Muscarinic Antagonist (M1,M2,M3) CNS - Penetrate CNS more rapidly Anti-DUMBBELSS (anti-emesis) Used to treat motion sickness
Benztropine Non-selective Muscarinic Antagonist (M1,M2,M3) CNS Anti-DUMBBELSS Used to treat Parkinson's
Tropicamide Muscarinic Antagonist Eyes Anti-DUMBBELSS Used for pupil dilation (block M3)
Tiotropium Selective Muscarinic Antagonist (M1 & M3) Lungs Anti-DUMBBELSS Heart rate not affected since it does not target M2 Long-Acting Muscarinic Antagonist (LAMA)
Aclidinium Umeclidinium Muscarinic Antagonist Lungs Anti-DUMBBELSS Long-Acting Muscarinic Antagonist (LAMA)
Oxybutynin Tolterodine Fesoterodine Solifenacin Darifenacin Trospium Non-selective Muscarinic Antagonist (M1,M2,M3) All are more selective for M3 M3 in Bladder Potential for Anti-DUMBBELSS (xerostomia and constipation) M3 Solifenacin, Darifenacin and Trospium are most selective for M3 ; Least likely to cause anti-DUMBBELSS
Nitroglycerin Nitroprusside Isosorbide di/mononitrate Donate Nitric Oxide NO -> sGC -> Increase cGMP Endothelium of Blood Vessels (M3) Vasodilation; Lower Blood Pressure cGMP is a potent Vasodilator
Sildenafil Tadalafil Vardenafil Blocks PDE -> Increase cGMP Endothelium of Blood Vessels (M3) Vasodilation; Lower Blood Pressure Blocks enzyme that breaks down cGMP = more cGMP ; Used for erectile dysfuntion
Created by: CalebL
 

 



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