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Toxoplasma gondii

QuestionAnswer
Routes of transmission Eating undercooked meat Cat feces Organ transplant
Life cycle Oocysts passed out in feces from cat. Intermediate host eats oocyst Sporozoites released Transforms into tachyzoites Circulate and infect host cells Reproduce until immune system catches up After two weeks the immune system attack the tachyzoites
Cats DH eats IH Tissue cysts(with bradyzoites) Zoites get released in intestine when tissue is broken down in stomach Infect intestinal cells Two rounds of merogony Gametogony Zygote Oocyst wall forms around the zygote
IH eats IH Ingest tissue cysts with bradyzoites Release of brady Transforms into tachyzoites Infects host cells Chooses cell and reproduce
At risk Fetus, Consuming undercooked beef Butchers, Raw meat on purpose or accident Gardeners Children via sandboxes Cat owners Immunocompromised
Pathology DH: usually asymptomatic Can kill young mammals IH: vast majority are asymptomatic More severe under certain situations Particular strain affects differently
Acute infection Circulating tachyzoites, Cats almost always asymptomatic Kittens show symptoms, Depends on which tissues are infected for humans (brain=neuro symptoms) IH will feels some symptoms when tachyzoites reproduce
Symptoms Swollen lymph nodes Inflammation Muscle pain Headache Fever
Chronic infection Bradyzoites Develops after two weeks, Signs depend on what's infected, Central nervous system, Encephalitis, Retina commonly infected, heart= myocarditis, Fetus
Congenital infection Hydrocephalus - inflammation in brain Mother has to be un acute infection for toxo to show Increases chances of stillbirth, low birth weight
Transplacental transmission 1st trimester transmission rate low, impact can be severe If infection happens later on, transmission rates are high, but development is mostly completed in case where pregnant person with acute cases is involved, only 45% of cases cross the placenta
Created by: aceofspades08
 

 



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