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Cholinergic Drugs

Pharmacology Exam 2

DrugMOASOASE / ADRsEK
Acetylcholine Methacholine Carbachol Bethanechol Non-selective Muscarinic Agonist (M1, M2, M3) Central and periphery DUMBBELSS
Pilocarpine Cevimeline Non-selective Muscarinic Agonist (M1, M2, M3) Central and periphery DUMBBELSS Treatment of dry mouth (enhance salivation) / glaucoma
Atropine Non-selective Muscarinic Antagonist (M1, M2, M3) Central and periphery Anti-DUMBBELSS Tachycardia, mydriasis, constipation, dry mouth, bronchial dilation, drowsiness Treatment of organophosphate poisoning (severe DUMBBELSS) Treatment of muscarinic agonist overdose
Scopolamine Non-selective Muscarinic Antagonist (M1, M2, M3) CNS – Penetrate CNS more rapidly Anti-DUMBBELSS (anti-emesis) Used to treat motion sickness
Benztropine (Cogentin) Non-selective Muscarinic Antagonist (M1, M2, M3) CNS Anti-DUMBBELSS Used to treat Parkinson’s
Tropicamide Muscarinic Antagonist Eyes Anti-DUMBBELSS Used for pupil dilation (block M3)
Ipratropium (Atrovent) Non-selective Muscarinic Antagonist (M1, M2, M3) Lungs Anti-DUMBBELSS Short-acting muscarinic antagonist (SAMA)
Tiotropium (Spiriva) SELECTIVE Muscarinic Antagonist (M1 & M3) Lungs Anti-DUMBELSS Heart rate not affected because it does not target M2 Long-acting muscarinic antagonist (LAMA)
Aclidinium Umeclidinium LA Muscarinic Antagonist Lungs Anti-DUMBBELSS Long-acting muscarinic antagonist (LAMA)
Oxybutynin (Ditropan) Tolterodine (Detrol) Fesoterodine (Toviaz) Solifenacin (Vesicare) Darifenacin Trospium Non-selective Muscarinic antagonist (M1, M2, M3) All are more selective for M3 M3 in Bladder All have potential to cause Anti-DUMBbELSs Xerostomia and constipation (M3) Solifenacin, Darifenacin, and Trospium are Most selective for M3  least likely to cause anti-DUMBbELSS Used to treat overactive bladder
Nitroglycerine Nitroprusside Isosorbide di or mononitrate Donate nitric oxide NO -> sGC -> ↑cGMP Endothelium of blood vessels (M3) Vasodilation Lower blood pressure cGMP is a potent vasodilator
Sildenafil (Viagra) Tadalafil (Cialis) Vardenafil Blocks PDE> increase cGMP Endothelium of blood vessels (M3) Vasodilation Lower blood pressure Blocks enzyme that breaks down cGMP = more cGMP Used to treat erectile dysfunction
Created by: PharmacistJulian
 

 



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