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Neuromuscular PCOL 2

Neuromuscular PCOL E2 Drug List

DrugsMOASOASide EffectsExtra Information
Acetylcholine Nicotinic & Muscarinic Depolarizing Agent (Agonist) All over body DUMBBELSS Diarrhea, Urination, Miosis, Bradycardia, Bronchial constriction, Emesis, Lacrimation, Salivation, Stimulation (CNS)
Varenicline α4/β2 Nn partial agonist CNS (Nn) Headache, insomnia, suicidal thoughts, depression, flatulence FDA warning of mood and behavioral changes; used for smoking cessation
Succinylcholine Depolarizing Agent (Neuromuscular blockade - nicotinic) (Agonist) NMJ (Nm) Can affect autonomic PNS/SNS ganglia NMJ Paralysis Hyperkalemia, HTN & arrhythmias, muscle pain (myalgia), hyperthermia Phase 1: binds to Ach binding space and keeps all Na+ channels open (cannot repolarize) Phase 2: blocks Na+ channels (cannot depolarize)
Physostigmine Cholinesterase Inhibitor (AChE Antagonist) CNS & periphery DUMBBELSS Penetrates CNS / cross BBB Treatment for anti-muscarinic poisoning (Atropine)
Donepezil Rivastigmine Galantamine Cholinesterase Inhibitor (AChE Antagonist) CNS & periphery DUMBBELSS Lipophilic (Cross BBB) Used for Dementia / Alzheimer's Longer T1/2 than Physostigmine
Pyridostigmine Neostigmine Cholinesterase Inhibitor (AChE Antagonist) NMJ DUMBBELSS No CNS Effects DO NOT cross BBB Reverse the effects of Curare/ treatment of myasthenia gravis
Edrophonium Cholinesterase Inhibitor (AChE Antagonist) NMJ DUMBBELSS No CNS Effects Used for diagnosis of myasthenia gravis or medication dose adjustments Short duration of action
Echothiophate Organophosphate Inhibitor of acetylcholinesterase enzyme M3 receptor in ciliary muscle (eye) Miosis and blurred vision, lacrimation, stinging / redness of eye Ophthalmology treatment glaucoma
Botulinum Toxin (Botox) Prevent ACh release Presynaptic terminal Muscle Relaxation Cleaves sites on SNARE protein
Curare & Curare Like Mivacurium Vecuronium Rocuronium Pancuronium Tubocurarine NON-depolarizing agent Direct competitive antagonist binds to ACh binding space NMJ NMJ Paralysis Histamine release, hypotension and tachycardia No CNS effects Doesn't allow ACh to bind; Ach is required for muscle contration
Created by: CalebL
 

 



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