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Phase II DME

PathwayEnzymesCo-factorsMechanismSubstrates
Glucuronidation UGT UDP-GA addition of a sugar molecule alcohols, carboxylic acids, aromatic amines, thiols, bilirubin
Sulfation ST, SULT PAPS addition of a sulfate group alkyl or aromatic alcohols, amines
Glutathione conjugation GST GSH addition of SG group electrophilic carbons
N-acetylation NAT1, NAT2 acetyl-CoA addition of an acetyl group on a nitrogen primary amines, SO2NH2
Amino acid conjugation AS acetyl-CoA, Gly, Glt addition of an amino acid in place of -OH carboxylic acids
Methylation COMT, PNMT SAM addition of a methyl group on a nucleophilic group -OH, -NH2, -SH
Created by: linabigsis
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