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Thyroid

QuestionAnswer
triiodothyronine T3
thyroxin T4
The thyroid is the only gland that can absorb iodine
Which is more potent T3 or T4 T3
Which has a shorter half life T3 or T4 T3
Which is unbound, active form that is monitored in pts Free T4
Hypotheyroidism deficiency in T4 elevation in TSH
drugs that can cause hypothyroidism Interferons, Tyrosine Kinase inhibitors: sunitinib Amiodarone, Lithium Carbamazepine, Others: oxcarbazepine, Eslicarbazepine, Phenytoin
Most common cause of hypothyroidism hashimotos disease
hashimoto disease autoimmune condition in which a pts own antibodies attack the thyroid gland
Myxedema coma fatal complication of hypothyroidism when left untreated or wheyn hypothyroidsm decompensates
how to treat myxedema coma IV levothyroxine
low free T4 range 0.9-2.3
high TSGH 0.3-3
when should you screen in pts > 60 y/o
when should you monitor TSH levels every 4-6 weeks until normal
triiodothyronine T3
thyroxin T4
The thyroid is the only gland that can absorb iodine
Which is more potent T3 or T4 T3
Which has a shorter half life T3 or T4 T3
Which is unbound, active form that is monitored in pts Free T4
Hypotheyroidism deficiency in T4 elevation in TSH
drugs that can cause hypothyroidism Interferons, Tyrosine Kinase inhibitors: sunitinib Amiodarone, Lithium Carbamazepine, Others: oxcarbazepine, Eslicarbazepine, Phenytoin
Most common cause of hypothyroidism hashimotos disease
hashimoto disease autoimmune condition in which a pts own antibodies attack the thyroid gland
Myxedema coma fatal complication of hypothyroidism when left untreated or wheyn hypothyroidsm decompensates
how to treat myxedema coma IV levothyroxine
free T4 range normal range 0.9-2.3
TSH normal range 0.3-3
when should you screen in pts > 60 y/o
when should you monitor TSH levels every 4-6 weeks until normal
too high of dose in elderly can cause AFib and fractures
after 4-6 weeks and levels are normal you check in 4-6 months
drug of choice for hypothyroidsm levothyroxine
Levothyroxine (T4) Synthroid
Levothyroxine (T4) Levooxyl
Levothyroxine (T4) Unithroid
Levothyroxine full replacement dose 1.6 mcg/kg/day
what weight do you use for levothryoxing dosing IBW
Pt with known CAD and needs to levothyroxine whats the initial dose 12.5 -25 mcg daily
thryroid desiccated USP (T3 and T4) Armour Thyroid Nature -Throid, NP Thyroid, Westhroid, WP Thyroid
Liothronine(t3) Cytomel
Liotrix T3 and T4 in 1:4 ratio thyrolar
decrease dose in what disease state cardiovascular disease
levothyroxine is a highly protein bound drug
How to take Levothyroxine PO with water same time each day at least 60 min before breakfast at bedtime: at least 3 hours after the last meal
Iv to PO ratio 0.75 to 1
which hypothyroidism treatment has a short half life causeing fluctuations in T3 levels Liothyronine
thyroid hormone replacement effect on warfarin increases warfarin
thyroid hormone replacement effect on theophylline decreases theophylline
what happens to thyroid replacement dose if you become preganat or plan to breast feed increase the dose
hyperthyroidism overactive thryoid
thyrotoxicosis Hyperthryoidism
Hyperthyroidism levels high T4 Low TSH
most common cause og hypotheyroidism graves disease
graves disease autoimmune disorder the antibodies stimulate the thyroid
drug induced causes of hyperthyroidism iodine, amiodarone, interferones
iodine induced hyperthroidism can be due to excess iodine in diet or expsoure to radiographic contrast media
Hyperthyroidism medications work by destroying part of the gland via radioactive iodine (RAI-131) OR Surgery
Pt with hyperthyroidism can have their symptoms of palipations, tremor, and tachycardia treated with beta blockers
to control hyperthyroidism symptoms how long does it take and what doses takes 1-3 months at high doses
Thionamides inhibit syntheisis of the thyroid `
PTU MOA thionamides AND inhibits peripheral conversion of T4 to T3
Propylthiouracil PTU
Methimazole MOA thinamides
why Hyperthroidism treatment is preferred in pregnanacy PTU
Boxed warning for PTU Severe liver injury and acute liver failure
Hyperthroidism treatment side effects GI upset
Hyperthroidism treatment warnings Heptatotoxicity agranulocytosisi DILE
Hyperthroidism treatment drug of choice Methimazole
Drug of choice in throid storm PTU
When is PTU preferred in pregnancy 1st trimester
If methimazole is used in pregnancy when can it be used 2nd and 3rd trimester to reduce risk of liver toxicicty from PTU
Iodides MOA temporarily secretion of thyroid only preventing stored hormone from being released
potassium iodide Lugols solution
saturated solution of potassium iodine SSKI
Potassium Iodide (KI) MOA blocks the accumulation of radioactive iodine int he thyroid gland thus preventing throid cancer
Thyroid storm life threatening medical emergency characterized by decompensated hyperthyroidism
symptoms of thyroid storm Fever > 103 Tachycardia Tachypnea Dehydration Profuse sweating Agitation Delirium Psychosis Coma
drug treatment for thyroid storm PTU is preferred + inorganic iodide therapy SSKI OR Lugols solution + BBlockers + dexamethasone + aggressive cooling
When is Potassium Iodide (KI) used after exposure to radiation
what beta blocker is used in thyroid storm treatment propranolol
what hypothyroidism treatment drug is safe in pregnancy and is preferred levothyroxine
Pregnant patients will be a what to their dose 30-50% increase in their dose
pregnant pts and hyperthyroidism drug of choice for 1st trimester PTU
pregnant pts and hyperthyroidism drug of choice for 2nd or 3rd trimester methimazole
Created by: annaiibarrera
 

 



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