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Oncology
naplex
| Question | Answer |
|---|---|
| when should breast, colorectal and lung cancers screening begin? | 45 for both breast and colorectal. 50 for lung |
| what are non specific cell cycle chemotherapy drugs? | cyclophosphamide, ifosfamide, the "rubicin", the "platins" |
| which chemotherapy work on G1? | Pegaspargase |
| which chemo works on S? | methotrexare, capectitabine, fluorouracil, "tecan" |
| which chemo works on G2? | Etoposide, bleomycin |
| Which chemo works on M | "Taxels", Vincristine, vinblastine |
| most chemo drugs use BSA for dosing, what is BSA formula? | square root of ((cm x kg)/3600) |
| what formula for carboplatin | AUC x (GFR +25) ----- GFR capped at 125 |
| what is used as a preventative with ifosfamide and cyclophospamide? | mesna |
| max cisplatin dose per cycle? | <100mg/m^2 |
| what is the life time cumulative dose of doxorubicin | 450-550 mg/m^2 |
| what is the chemoprotectant used with doxorubicin? | dexrazoxane when cumulative dose >300 mg/m^2 |
| what is used to offset the diarrhea caused by irenotecan? | acute: atropine delayed: loperamide |
| what is the max vincristine dose? | 2mg per dose. regardless of BSA |
| what medication is usually given with fluorouracil to imrpove efficacy? | leucovorin |
| what is used as rescue from methotrexate? | leucovorin. the antidoe is glucarpidase |
| what is the lifetime cumulative dose of bleomycin? | 400 units |
| what can be used to prevent nephrotixicity associated with cisplatin? | amifostine |
| which chemos are not associated with myelopsuppression? | bloemycin, vincristin, pegasparagase |
| aboslute neutrophil count formula? | ((%segments + % bands) x WBC) / 100 |
| neutropenia definitions | neutropenia <1,000 severe neutropenia <500 profound neutropenia <100 |
| what colony stimulating factors used to increase WBC in chemo patients? | filgrastim (neupogen), pegfligrastim (neulasta) |
| when to administer the G- colony stimulating factors in chemo patients? | no sooner than 24 hrs after chemo |
| if patient is sick while neutropenic from chemo and expected to remain neutropenic for less than 7 days what drugs? | FQ + augmentin ORAL |
| if patient is sick while neutropenic from chemo and expected to remain neutropenic for more than 7 days what drugs? | IV PSDM coverage |
| breast cancer prevention drugs? | premenopausal: tamoxifen postmenopausal: any SERM or aromatase inhibitors (anastrazole) |
| hormone therapy for prostate cancer? | GnRH agonist +antiandrogen GnRH antagonist alone |
| what is ur GnRH agonist: | Leuprolid, gosereline |
| what is ur antiandrogens | "tamide" bicalutamide |
| what is ur GnRH antagonists | degarelix or relugolix |
| what are the complications to tumor lysis syndrome? | hyper K, hyperuricemia, AKI, hypocalcemia |
| treatment for tumor lysis syndrome? | Fluids + urate lowerin therapies |
Created by:
saif1206