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Test 1 Koch

Test 1 Koch History

QuestionAnswer
What was Koch's (1876) major contribution? Koch's POSTULATES: FIRST showing particular organism as CAUSE of a particular DISEASE
T/F Are Koch's Postulates applicable/possible for ALL organisms and diseases? False
What are Koch's 4 Postulates? 1. SPECIFIC ORGAN in EVERY SPECIFIC DISEASE, NO in healthy subject 2. organ ISOLATE fr host & grow to PURE CULT in-vitro 3. organ fr PURE CULT -> SAME DISEASE when inoculat in HEALTHY 4. organ ISOLATED AGAIN fr inoculat subj & GROWN AGAIN in PURE CULT
What are 5 EXCEPTIONS to Koch's 1st Postulate: "The specific organism must be found in EVERY case of the specific disease, but not in healthy subjects" 1. Mycobacterium tuberculosis = TB 2. Staphylococcus aureus = MRSA 3. Escherichia coli = E. coli 4. Streptococcus pneumoniae = pneumonia 5. Neisseria gonorrhoeae = gonorrhea
How does "Escherichia coli" (E. coli) violate Koch's 1st Postulate: "The specific organism must be found in EVERY case of the specific disease, but not in healthy subjects" Normal in intestines, cause UTIs (Urinary Tract Infections) if goes elsewhere.
How does "Streptococcus pneumoniae" (pneumonia) violate Koch's 1st Postulate: "The specific organism must be found in EVERY case of the specific disease, but not in healthy subjects" 1. Found in 40% of healthy individuals in the naso-pharynx. 2. Normal in Nasopharynx, but can problems if goes to CNS.
How does "Neisseria gonorrhoeae" (gonorrhea) violate Koch's 1st Postulate: "The specific organism must be found in EVERY case of the specific disease, but not in healthy subjects" 1. Gram negative cocci. 2. Mostly HEALTHY females are asymptomatic CARRIERS
What are 3 EXCEPTIONS to Koch's 2nd Postulate: "The organism must be isolated from the diseased host and grown in pure culture in vitro in the lab" 1. Viruses 2. Treponema pallidum = syphillis 3. Mycobacterium leprae = leprosy/Hansen's disease
How does "Treponema pallidum" (syphillis) violate Koch's 2nd Postulate: "The organism must be isolated from the diseased host and grown in pure culture in vitro in the lab" Needs to be grown in rabbit testes
How does "Mycobacterium leprae" (leprosy/Hansen's disease) violate Koch's 2nd Postulate: "The organism must be isolated from the diseased host and grown in pure culture in vitro in the lab" 1. Need to be grown in armadillo foot pads. 2. Slow-growing bacteria.
T/F Koch's 2nd & 4th postulates have the SAME EXCEPTIONS. 2nd: "The organism must be isolated from the diseased host and grown in pure culture in vitro in the lab" 4th: "same organism isolated again from inoculated subject and grown again in pure cultur True
What was Koch's occupation in the 1800s? German Physician
What bacteria and Koch postulate for: "1. Need to be grown in armadillo foot pads. 2. Slow-growing bacteria." "Mycobacterium leprae" (leprosy/Hansen's disease) violate Koch's 2nd Postulate: "The organism must be isolated from the diseased host and grown in pure culture in vitro in the lab"
What bacteria and Koch postulate for: "Needs to be grown in rabbit testes" "Treponema pallidum" (syphillis) violate Koch's 2nd Postulate: "The organism must be isolated from the diseased host and grown in pure culture in vitro in the lab"
What bacteria and Koch postulate for: "1. Gram negative cocci. 2. Mostly HEALTHY females are asymptomatic CARRIERS" "Neisseria gonorrhoeae" (gonorrhea) violate Koch's 1st Postulate: "The specific organism must be found in EVERY case of the specific disease, but not in healthy subjects"
What bacteria and Koch postulate for: "1. Found in 40% of healthy individuals in the naso-pharynx. 2. Normal in Nasopharynx, but can problems if goes to CNS." "Streptococcus pneumoniae" (pneumonia) violate Koch's 1st Postulate: "The specific organism must be found in EVERY case of the specific disease, but not in healthy subjects"
What bacteria and Koch postulate for: "Normal in intestines, cause UTIs (Urinary Tract Infections) if goes elsewhere." "Escherichia coli" (E. coli) violate Koch's 1st Postulate: "The specific organism must be found in EVERY case of the specific disease, but not in healthy subjects"
Created by: jviloria2
 

 



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